3goc: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3goc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_avermitilis Streptomyces avermitilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GOC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GOC FirstGlance]. <br> | <table><tr><td colspan='2'>[[3goc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_avermitilis Streptomyces avermitilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GOC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GOC FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=YES:3-(2-HYDROXYETHYL)-2,2-BIS(HYDROXYMETHYL)PENTANE-1,5-DIOL'>YES</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=YES:3-(2-HYDROXYETHYL)-2,2-BIS(HYDROXYMETHYL)PENTANE-1,5-DIOL'>YES</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">nfi ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=33903 Streptomyces avermitilis])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">nfi ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=33903 Streptomyces avermitilis])</td></tr> | ||
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Deoxyribonuclease_V Deoxyribonuclease V], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.21.7 3.1.21.7] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Deoxyribonuclease_V Deoxyribonuclease V], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.21.7 3.1.21.7] </span></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3goc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3goc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3goc RCSB], [http://www.ebi.ac.uk/pdbsum/3goc PDBsum], [http://www.topsan.org/Proteins/NESGC/3goc TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3goc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3goc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3goc RCSB], [http://www.ebi.ac.uk/pdbsum/3goc PDBsum], [http://www.topsan.org/Proteins/NESGC/3goc TOPSAN]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/NFI_STRAW NFI_STRAW]] DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA (By similarity).[HAMAP-Rule:MF_00801] | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Deoxyribonuclease V]] | [[Category: Deoxyribonuclease V]] | ||
[[Category: Streptomyces avermitilis]] | [[Category: Streptomyces avermitilis]] | ||
[[Category: Abashidze, M | [[Category: Abashidze, M]] | ||
[[Category: Acton, T B | [[Category: Acton, T B]] | ||
[[Category: Chen, C X | [[Category: Chen, C X]] | ||
[[Category: Cunningham, K | [[Category: Cunningham, K]] | ||
[[Category: Everett, J K | [[Category: Everett, J K]] | ||
[[Category: Fang, F | [[Category: Fang, F]] | ||
[[Category: Forouhar, F | [[Category: Forouhar, F]] | ||
[[Category: Hunt, J F | [[Category: Hunt, J F]] | ||
[[Category: Hussain, M | [[Category: Hussain, M]] | ||
[[Category: Ma, L | [[Category: Ma, L]] | ||
[[Category: Montelione, G T | [[Category: Montelione, G T]] | ||
[[Category: | [[Category: Structural genomic]] | ||
[[Category: Nair, R | [[Category: Nair, R]] | ||
[[Category: Owens, L | [[Category: Owens, L]] | ||
[[Category: Rost, B | [[Category: Rost, B]] | ||
[[Category: Seetharaman, J | [[Category: Seetharaman, J]] | ||
[[Category: Tong, L | [[Category: Tong, L]] | ||
[[Category: Xiao, R | [[Category: Xiao, R]] | ||
[[Category: Alpha-beta protein]] | [[Category: Alpha-beta protein]] | ||
[[Category: Dna damage]] | [[Category: Dna damage]] | ||
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[[Category: Magnesium]] | [[Category: Magnesium]] | ||
[[Category: Nesg]] | [[Category: Nesg]] | ||
[[Category: Nuclease]] | [[Category: Nuclease]] | ||
[[Category: Protein structure initiative | [[Category: PSI, Protein structure initiative]] | ||
