1gnh: Difference between revisions
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|PDB= 1gnh |SIZE=350|CAPTION= <scene name='initialview01'>1gnh</scene>, resolution 3.0Å | |PDB= 1gnh |SIZE=350|CAPTION= <scene name='initialview01'>1gnh</scene>, resolution 3.0Å | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand=CA:CALCIUM ION'>CA</scene> | |LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY= | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gnh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gnh OCA], [http://www.ebi.ac.uk/pdbsum/1gnh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1gnh RCSB]</span> | |||
}} | }} | ||
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==Overview== | ==Overview== | ||
The structure of the classical acute phase reactant human C-reactive protein provides evidence that phosphocholine binding is mediated through calcium and a hydrophobic pocket centred on Phe 66. The residue Glu 81 is suitably positioned to interact with the choline group. A cleft on the pentameric face opposite to that containing the calcium site may have an important functional role. The structure provides insights into the molecular mechanisms by which this highly conserved plasma protein, for which no polymorphism or deficiency state is known, may exert its biological role. | The structure of the classical acute phase reactant human C-reactive protein provides evidence that phosphocholine binding is mediated through calcium and a hydrophobic pocket centred on Phe 66. The residue Glu 81 is suitably positioned to interact with the choline group. A cleft on the pentameric face opposite to that containing the calcium site may have an important functional role. The structure provides insights into the molecular mechanisms by which this highly conserved plasma protein, for which no polymorphism or deficiency state is known, may exert its biological role. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Turnell, W G.]] | [[Category: Turnell, W G.]] | ||
[[Category: Volanakis, J E.]] | [[Category: Volanakis, J E.]] | ||
[[Category: acute-phase protein]] | [[Category: acute-phase protein]] | ||
[[Category: acute-phase reactant]] | [[Category: acute-phase reactant]] | ||
[[Category: pentraxin]] | [[Category: pentraxin]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:47:43 2008'' | ||
