3ks9: Difference between revisions

Revision as of 10:08, 20 January 2015

Metabotropic glutamate receptor mGluR1 complexed with LY341495 antagonist

Structural highlights

3ks9 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	MG, NAG, Z99
Gene:	GPRC1A, GRM1, MGLUR1 (Homo sapiens)
Resources:	FirstGlance, OCA, RCSB, PDBsum

Disease

[GRM1_HUMAN] Autosomal recessive congenital cerebellar ataxia due to MGLUR1 deficiency. The disease is caused by mutations affecting the gene represented in this entry.^[1]

Function

[GRM1_HUMAN] G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum.^[2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Guergueltcheva V, Azmanov DN, Angelicheva D, Smith KR, Chamova T, Florez L, Bynevelt M, Nguyen T, Cherninkova S, Bojinova V, Kaprelyan A, Angelova L, Morar B, Chandler D, Kaneva R, Bahlo M, Tournev I, Kalaydjieva L. Autosomal-recessive congenital cerebellar ataxia is caused by mutations in metabotropic glutamate receptor 1. Am J Hum Genet. 2012 Sep 7;91(3):553-64. doi: 10.1016/j.ajhg.2012.07.019. Epub, 2012 Aug 16. PMID:22901947 doi:https://dx.doi.org/10.1016/j.ajhg.2012.07.019
↑ Desai MA, Burnett JP, Mayne NG, Schoepp DD. Cloning and expression of a human metabotropic glutamate receptor 1 alpha: enhanced coupling on co-transfection with a glutamate transporter. Mol Pharmacol. 1995 Oct;48(4):648-57. PMID:7476890

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OCA

[1] Guergueltcheva V, Azmanov DN, Angelicheva D, Smith KR, Chamova T, Florez L, Bynevelt M, Nguyen T, Cherninkova S, Bojinova V, Kaprelyan A, Angelova L, Morar B, Chandler D, Kaneva R, Bahlo M, Tournev I, Kalaydjieva L. Autosomal-recessive congenital cerebellar ataxia is caused by mutations in metabotropic glutamate receptor 1. Am J Hum Genet. 2012 Sep 7;91(3):553-64. doi: 10.1016/j.ajhg.2012.07.019. Epub, 2012 Aug 16. PMID:22901947 doi:https://dx.doi.org/10.1016/j.ajhg.2012.07.019

[2] Desai MA, Burnett JP, Mayne NG, Schoepp DD. Cloning and expression of a human metabotropic glutamate receptor 1 alpha: enhanced coupling on co-transfection with a glutamate transporter. Mol Pharmacol. 1995 Oct;48(4):648-57. PMID:7476890

[1]

[2]

@@ Line 3: / Line 3: @@
 == Structural highlights ==
 <table><tr><td colspan='2'>[[3ks9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KS9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KS9 FirstGlance]. <br>
-</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=Z99:2-[(1S,2S)-2-CARBOXYCYCLOPROPYL]-3-(9H-XANTHEN-9-YL)-D-ALANINE'>Z99</scene><br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=Z99:2-[(1S,2S)-2-CARBOXYCYCLOPROPYL]-3-(9H-XANTHEN-9-YL)-D-ALANINE'>Z99</scene></td></tr>
-<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GPRC1A, GRM1, MGLUR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GPRC1A, GRM1, MGLUR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ks9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ks9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ks9 RCSB], [http://www.ebi.ac.uk/pdbsum/3ks9 PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ks9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ks9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ks9 RCSB], [http://www.ebi.ac.uk/pdbsum/3ks9 PDBsum]</span></td></tr>
-<table>
+</table>
 == Disease ==
 [[http://www.uniprot.org/uniprot/GRM1_HUMAN GRM1_HUMAN]] Autosomal recessive congenital cerebellar ataxia due to MGLUR1 deficiency. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:22901947</ref>
@@ Line 29: / Line 29: @@
 </StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Arrowsmith, C H.]]
+[[Category: Arrowsmith, C H]]
-[[Category: Bochkarev, A.]]
+[[Category: Bochkarev, A]]
-[[Category: Bountra, C.]]
+[[Category: Bountra, C]]
-[[Category: Cossar, D.]]
+[[Category: Cossar, D]]
-[[Category: Dobrovetsky, E.]]
+[[Category: Dobrovetsky, E]]
-[[Category: Edwards, A M.]]
+[[Category: Edwards, A M]]
-[[Category: Khutoreskaya, G.]]
+[[Category: Khutoreskaya, G]]
-[[Category: SGC, Structural Genomics Consortium.]]
+[[Category: Structural genomic]]
-[[Category: Seitova, A.]]
+[[Category: Seitova, A]]
-[[Category: Weigelt, J.]]
+[[Category: Weigelt, J]]
 [[Category: Cell membrane]]
 [[Category: Dimerization]]
@@ Line 51: / Line 51: @@
 [[Category: Sgc]]
 [[Category: Signaling protein]]
-[[Category: Structural genomic]]
-[[Category: Structural genomics consortium]]
 [[Category: Transducer]]
 [[Category: Transmembrane]]

3ks9: Difference between revisions

Revision as of 10:08, 20 January 2015

Metabotropic glutamate receptor mGluR1 complexed with LY341495 antagonist

Structural highlights

Disease

Function

Evolutionary Conservation

See Also

References

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