3inq: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3inq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3INQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3INQ FirstGlance]. <br> | <table><tr><td colspan='2'>[[3inq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3INQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3INQ FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=X0J:4-[4-(BIPHENYL-3-YLMETHYL)PIPERAZIN-1-YL]-N-{[4-({(1R)-3-(DIMETHYLAMINO)-1-[(PHENYLSULFANYL)METHYL]PROPYL}AMINO)-3-NITROPHENYL]SULFONYL}BENZAMIDE'>X0J</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=X0J:4-[4-(BIPHENYL-3-YLMETHYL)PIPERAZIN-1-YL]-N-{[4-({(1R)-3-(DIMETHYLAMINO)-1-[(PHENYLSULFANYL)METHYL]PROPYL}AMINO)-3-NITROPHENYL]SULFONYL}BENZAMIDE'>X0J</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2yxj|2yxj]], [[3fdl|3fdl]], [[2p1l|2p1l]], [[3io8|3io8]], [[3io9|3io9]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2yxj|2yxj]], [[3fdl|3fdl]], [[2p1l|2p1l]], [[3io8|3io8]], [[3io9|3io9]]</td></tr> | ||
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BCL-X ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BCL-X ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3inq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3inq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3inq RCSB], [http://www.ebi.ac.uk/pdbsum/3inq PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3inq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3inq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3inq RCSB], [http://www.ebi.ac.uk/pdbsum/3inq PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
*[[Bcl-2|Bcl-2]] | *[[Bcl-2|Bcl-2]] | ||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Colman, P M | [[Category: Colman, P M]] | ||
[[Category: Czabotar, P E | [[Category: Czabotar, P E]] | ||
[[Category: Fairlie, W D | [[Category: Fairlie, W D]] | ||
[[Category: Lee, E F | [[Category: Lee, E F]] | ||
[[Category: Smith, B J | [[Category: Smith, B J]] | ||
[[Category: Apoptosis]] | [[Category: Apoptosis]] | ||
[[Category: Membrane]] | [[Category: Membrane]] | ||
Revision as of 13:49, 24 December 2014
Crystal structure of BCL-XL in complex with W1191542
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