1h04: Difference between revisions
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|PDB= 1h04 |SIZE=350|CAPTION= <scene name='initialview01'>1h04</scene>, resolution 2.0Å | |PDB= 1h04 |SIZE=350|CAPTION= <scene name='initialview01'>1h04</scene>, resolution 2.0Å | ||
|SITE= <scene name='pdbsite=AC1:Ni+Binding+Site+For+Chain+P'>AC1</scene> | |SITE= <scene name='pdbsite=AC1:Ni+Binding+Site+For+Chain+P'>AC1</scene> | ||
|LIGAND= <scene name='pdbligand=NI:NICKEL (II) ION'>NI</scene> | |LIGAND= <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY= | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h04 OCA], [http://www.ebi.ac.uk/pdbsum/1h04 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1h04 RCSB]</span> | |||
}} | }} | ||
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==Overview== | ==Overview== | ||
Decay-accelerating factor (CD55), a regulator of the alternative and classical pathways of complement activation, is expressed on all serum-exposed cells. It is used by pathogens, including many enteroviruses and uropathogenic Escherichia coli, as a receptor prior to infection. We describe the x-ray structure of a pathogen-binding fragment of human CD55 at 1.7 A resolution containing two of the three domains required for regulation of human complement. We have used mutagenesis to map biological functions onto the molecule; decay-accelerating activity maps to a single face of the molecule, whereas bacterial and viral pathogens recognize a variety of different sites on CD55. | Decay-accelerating factor (CD55), a regulator of the alternative and classical pathways of complement activation, is expressed on all serum-exposed cells. It is used by pathogens, including many enteroviruses and uropathogenic Escherichia coli, as a receptor prior to infection. We describe the x-ray structure of a pathogen-binding fragment of human CD55 at 1.7 A resolution containing two of the three domains required for regulation of human complement. We have used mutagenesis to map biological functions onto the molecule; decay-accelerating activity maps to a single face of the molecule, whereas bacterial and viral pathogens recognize a variety of different sites on CD55. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Spiller, B.]] | [[Category: Spiller, B.]] | ||
[[Category: Williams, P.]] | [[Category: Williams, P.]] | ||
[[Category: alternative splicing]] | [[Category: alternative splicing]] | ||
[[Category: bacterial receptor]] | [[Category: bacterial receptor]] | ||
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[[Category: ligand for cd97]] | [[Category: ligand for cd97]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:54:59 2008'' | ||
Revision as of 17:55, 30 March 2008
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| 1h04, resolution 2.0Å | |||||||||||||
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| Sites: | AC1 | ||||||||||||
| Ligands: | NI | ||||||||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
HUMAN CD55 DOMAINS 3 & 4
Overview
Decay-accelerating factor (CD55), a regulator of the alternative and classical pathways of complement activation, is expressed on all serum-exposed cells. It is used by pathogens, including many enteroviruses and uropathogenic Escherichia coli, as a receptor prior to infection. We describe the x-ray structure of a pathogen-binding fragment of human CD55 at 1.7 A resolution containing two of the three domains required for regulation of human complement. We have used mutagenesis to map biological functions onto the molecule; decay-accelerating activity maps to a single face of the molecule, whereas bacterial and viral pathogens recognize a variety of different sites on CD55.
About this Structure
1H04 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Mapping CD55 function. The structure of two pathogen-binding domains at 1.7 A., Williams P, Chaudhry Y, Goodfellow IG, Billington J, Powell R, Spiller OB, Evans DJ, Lea S, J Biol Chem. 2003 Mar 21;278(12):10691-6. Epub 2002 Dec 22. PMID:12499389
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