1p93: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1p93]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P93 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P93 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1p93]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P93 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P93 FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DEX:DEXAMETHASONE'>DEX</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DEX:DEXAMETHASONE'>DEX</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1nhz|1nhz]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1nhz|1nhz]]</td></tr> | ||
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NR3C1 or GRL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NR3C1 or GRL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p93 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1p93 RCSB], [http://www.ebi.ac.uk/pdbsum/1p93 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p93 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1p93 RCSB], [http://www.ebi.ac.uk/pdbsum/1p93 PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/GCR_HUMAN GCR_HUMAN]] Defects in NR3C1 are a cause of glucocorticoid resistance (GCRES) [MIM:[http://omim.org/entry/138040 138040]]; also known as cortisol resistance. It is a hypertensive, hyperandrogenic disorder characterized by increased serum cortisol concentrations. Inheritance is autosomal dominant.<ref>PMID:12050230</ref> <ref>PMID:1704018</ref> <ref>PMID:7683692</ref> <ref>PMID:11589680</ref> <ref>PMID:11701741</ref> [[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation. | [[http://www.uniprot.org/uniprot/GCR_HUMAN GCR_HUMAN]] Defects in NR3C1 are a cause of glucocorticoid resistance (GCRES) [MIM:[http://omim.org/entry/138040 138040]]; also known as cortisol resistance. It is a hypertensive, hyperandrogenic disorder characterized by increased serum cortisol concentrations. Inheritance is autosomal dominant.<ref>PMID:12050230</ref> <ref>PMID:1704018</ref> <ref>PMID:7683692</ref> <ref>PMID:11589680</ref> <ref>PMID:11701741</ref> [[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation. | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Ahola, H | [[Category: Ahola, H]] | ||
[[Category: Alarcon, M | [[Category: Alarcon, M]] | ||
[[Category: Calles, K | [[Category: Calles, K]] | ||
[[Category: Carlquist, M | [[Category: Carlquist, M]] | ||
[[Category: Carlstedt-Duke, J | [[Category: Carlstedt-Duke, J]] | ||
[[Category: Engstrom, O | [[Category: Engstrom, O]] | ||
[[Category: Farnegardh, M | [[Category: Farnegardh, M]] | ||
[[Category: Greer, J | [[Category: Greer, J]] | ||
[[Category: Gustafsson, J A | [[Category: Gustafsson, J A]] | ||
[[Category: Harlan, J | [[Category: Harlan, J]] | ||
[[Category: Jakob, C | [[Category: Jakob, C]] | ||
[[Category: Kauppi, B | [[Category: Kauppi, B]] | ||
[[Category: Muchmore, S | [[Category: Muchmore, S]] | ||
[[Category: Ohman, L | [[Category: Ohman, L]] | ||
[[Category: Ramqvist, A K | [[Category: Ramqvist, A K]] | ||
[[Category: Thorell, S | [[Category: Thorell, S]] | ||
[[Category: Yang, J | [[Category: Yang, J]] | ||
[[Category: Anti parallel alpha helix sandwich]] | [[Category: Anti parallel alpha helix sandwich]] | ||
[[Category: Hormone receptor]] | [[Category: Hormone receptor]] | ||
[[Category: Protien-ligand complex]] | [[Category: Protien-ligand complex]] | ||
