1bgo: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1bgo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BGO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BGO FirstGlance]. <br> | <table><tr><td colspan='2'>[[1bgo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BGO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BGO FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=I10:1-[2-(3-BIPHENYL)-4-METHYLVALERYL)]AMINO-3-(2-PYRIDYLSULFONYL)AMINO-2-PROPANONE'>I10</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=I10:1-[2-(3-BIPHENYL)-4-METHYLVALERYL)]AMINO-3-(2-PYRIDYLSULFONYL)AMINO-2-PROPANONE'>I10</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_K Cathepsin K], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.38 3.4.22.38] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_K Cathepsin K], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.38 3.4.22.38] </span></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bgo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bgo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bgo RCSB], [http://www.ebi.ac.uk/pdbsum/1bgo PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bgo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bgo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bgo RCSB], [http://www.ebi.ac.uk/pdbsum/1bgo PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN]] Defects in CTSK are the cause of pycnodysostosis (PKND) [MIM:[http://omim.org/entry/265800 265800]]. PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature.<ref>PMID:8703060</ref> <ref>PMID:9529353</ref> <ref>PMID:10491211</ref> <ref>PMID:10878663</ref> | [[http://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN]] Defects in CTSK are the cause of pycnodysostosis (PKND) [MIM:[http://omim.org/entry/265800 265800]]. PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature.<ref>PMID:8703060</ref> <ref>PMID:9529353</ref> <ref>PMID:10491211</ref> <ref>PMID:10878663</ref> | ||
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[[Category: Cathepsin K]] | [[Category: Cathepsin K]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Abdel-Meguid, S S | [[Category: Abdel-Meguid, S S]] | ||
[[Category: Alessio, K D | [[Category: Alessio, K D]] | ||
[[Category: Allen, A C | [[Category: Allen, A C]] | ||
[[Category: Bondinell, W E | [[Category: Bondinell, W E]] | ||
[[Category: Desjarlais, R L | [[Category: Desjarlais, R L]] | ||
[[Category: Erhard, K F | [[Category: Erhard, K F]] | ||
[[Category: Haltiwanger, R C | [[Category: Haltiwanger, R C]] | ||
[[Category: Janson, C A | [[Category: Janson, C A]] | ||
[[Category: Levy, M A | [[Category: Levy, M A]] | ||
[[Category: Mcqueney, M S | [[Category: Mcqueney, M S]] | ||
[[Category: Oh, H J | [[Category: Oh, H J]] | ||
[[Category: Smith, W W | [[Category: Smith, W W]] | ||
[[Category: Tomaszek, T A | [[Category: Tomaszek, T A]] | ||
[[Category: Uzinskas, I N | [[Category: Uzinskas, I N]] | ||
[[Category: Veber, D F | [[Category: Veber, D F]] | ||
[[Category: Yamashita, D S | [[Category: Yamashita, D S]] | ||
[[Category: Zhao, B | [[Category: Zhao, B]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Sulfhydryl proteinase]] | [[Category: Sulfhydryl proteinase]] | ||
[[Category: Thiol protease]] | [[Category: Thiol protease]] | ||
Revision as of 12:10, 22 December 2014
CRYSTAL STRUCTURE OF CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH A COVALENT PEPTIDOMIMETIC INHIBITOR
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