1h8t: Difference between revisions
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|PDB= 1h8t |SIZE=350|CAPTION= <scene name='initialview01'>1h8t</scene>, resolution 2.90Å | |PDB= 1h8t |SIZE=350|CAPTION= <scene name='initialview01'>1h8t</scene>, resolution 2.90Å | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand=DOA:12-AMINO-DODECANOIC+ACID'>DOA</scene> | |LIGAND= <scene name='pdbligand=DOA:12-AMINO-DODECANOIC+ACID'>DOA</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY= | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h8t OCA], [http://www.ebi.ac.uk/pdbsum/1h8t PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1h8t RCSB]</span> | |||
}} | }} | ||
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==About this Structure== | ==About this Structure== | ||
1H8T is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ | 1H8T is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Human_echovirus_11 Human echovirus 11]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H8T OCA]. | ||
==Reference== | ==Reference== | ||
Determination of the structure of a decay accelerating factor-binding clinical isolate of echovirus 11 allows mapping of mutants with altered receptor requirements for infection., Stuart AD, McKee TA, Williams PA, Harley C, Shen S, Stuart DI, Brown TD, Lea SM, J Virol. 2002 Aug;76(15):7694-704. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12097583 12097583] | Determination of the structure of a decay accelerating factor-binding clinical isolate of echovirus 11 allows mapping of mutants with altered receptor requirements for infection., Stuart AD, McKee TA, Williams PA, Harley C, Shen S, Stuart DI, Brown TD, Lea SM, J Virol. 2002 Aug;76(15):7694-704. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12097583 12097583] | ||
[[Category: Human echovirus | [[Category: Human echovirus 11]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Brown, T D.K.]] | [[Category: Brown, T D.K.]] | ||
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[[Category: Stuart, D I.]] | [[Category: Stuart, D I.]] | ||
[[Category: Williams, P A.]] | [[Category: Williams, P A.]] | ||
[[Category: echovirus]] | [[Category: echovirus]] | ||
[[Category: icosahedral virus]] | [[Category: icosahedral virus]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:00:07 2008'' | ||
Revision as of 18:00, 30 March 2008
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| 1h8t, resolution 2.90Å | |||||||||||||
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| Ligands: | DOA, MYR | ||||||||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
ECHOVIRUS 11
Overview
We have used X-ray crystallography to determine the structure of a decay accelerating factor (DAF)-binding, clinic-derived isolate of echovirus 11 (EV11-207). The structures of the capsid proteins closely resemble those of capsid proteins of other picornaviruses. The structure allows us to interpret a series of amino acid changes produced by passaging EV11-207 in different cell lines as highlighting the locations of multiple receptor-binding sites on the virion surface. We suggest that a DAF-binding site is located at the fivefold axes of the virion, while the binding site for a distinct but as yet unidentified receptor is located within the canyon surrounding the virion fivefold axes.
About this Structure
1H8T is a Protein complex structure of sequences from Human echovirus 11. Full crystallographic information is available from OCA.
Reference
Determination of the structure of a decay accelerating factor-binding clinical isolate of echovirus 11 allows mapping of mutants with altered receptor requirements for infection., Stuart AD, McKee TA, Williams PA, Harley C, Shen S, Stuart DI, Brown TD, Lea SM, J Virol. 2002 Aug;76(15):7694-704. PMID:12097583
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