1i30: Difference between revisions
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|PDB= 1i30 |SIZE=350|CAPTION= <scene name='initialview01'>1i30</scene>, resolution 2.4Å | |PDB= 1i30 |SIZE=350|CAPTION= <scene name='initialview01'>1i30</scene>, resolution 2.4Å | ||
|SITE= | |SITE= | ||
|LIGAND= | |LIGAND= <scene name='pdbligand=826:1,3,4,9-TETRAHYDRO-2-(HYDROXYBENZOYL)-9-[(4-HYDROXYPHENYL)METHYL]-6-METHOXY-2H-PYRIDO[3,4-B]INDOLE'>826</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene> | ||
|ACTIVITY= [http://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9] | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9] </span> | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY=[[1c14|1C14]], [[1i2z|1I2Z]] | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i30 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i30 OCA], [http://www.ebi.ac.uk/pdbsum/1i30 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1i30 RCSB]</span> | |||
}} | }} | ||
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[[Category: Qiu, X.]] | [[Category: Qiu, X.]] | ||
[[Category: Seefeld, M A.]] | [[Category: Seefeld, M A.]] | ||
[[Category: acp]] | [[Category: acp]] | ||
[[Category: antibiotic]] | [[Category: antibiotic]] | ||
[[Category: enoyl reductase]] | [[Category: enoyl reductase]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:13:52 2008'' | ||
Revision as of 18:13, 30 March 2008
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| 1i30, resolution 2.4Å | |||||||||||||
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| Ligands: | 826, NAD | ||||||||||||
| Activity: | [acyl-carrier-protein_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number 1.3.1.9 | ||||||||||||
| Related: | 1C14, 1I2Z
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
E. COLI ENOYL REDUCTASE +NAD+SB385826
Overview
1,4-Disubstituted imidazole inhibitors of Staphylococcus aureus and Escherichia coli enoyl acyl carrier protein reductase (FabI) have been identified. Crystal structure data shows the inhibitor 1 bound in the enzyme active site of E. coli FabI.
About this Structure
1I30 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI)., Heerding DA, Chan G, DeWolf WE, Fosberry AP, Janson CA, Jaworski DD, McManus E, Miller WH, Moore TD, Payne DJ, Qiu X, Rittenhouse SF, Slater-Radosti C, Smith W, Takata DT, Vaidya KS, Yuan CC, Huffman WF, Bioorg Med Chem Lett. 2001 Aug 20;11(16):2061-5. PMID:11514139 [[Category: Enoyl-[acyl-carrier-protein] reductase (NADH)]]
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