2i59: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2i59]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I59 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I59 FirstGlance]. <br> | <table><tr><td colspan='2'>[[2i59]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I59 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I59 FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RGS10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RGS10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i59 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2i59 RCSB], [http://www.ebi.ac.uk/pdbsum/2i59 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i59 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2i59 RCSB], [http://www.ebi.ac.uk/pdbsum/2i59 PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/RGS10_HUMAN RGS10_HUMAN]] Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Associates specifically with the activated forms of the G protein subunits G(i)-alpha and G(z)-alpha but fails to interact with the structurally and functionally distinct G(s)-alpha subunit. Activity on G(z)-alpha is inhibited by palmitoylation of the G-protein. | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Arrowsmith, C | [[Category: Arrowsmith, C]] | ||
[[Category: Ball, L J | [[Category: Ball, L J]] | ||
[[Category: Diehl, A | [[Category: Diehl, A]] | ||
[[Category: Doyle, D A | [[Category: Doyle, D A]] | ||
[[Category: Edwards, A | [[Category: Edwards, A]] | ||
[[Category: Elkins, J | [[Category: Elkins, J]] | ||
[[Category: Fedorov, O | [[Category: Fedorov, O]] | ||
[[Category: Higman, V A | [[Category: Higman, V A]] | ||
[[Category: Leidert, M | [[Category: Leidert, M]] | ||
[[Category: Lemak, A | [[Category: Lemak, A]] | ||
[[Category: Oschkinat, H | [[Category: Oschkinat, H]] | ||
[[Category: | [[Category: Structural genomic]] | ||
[[Category: Schmieder, P | [[Category: Schmieder, P]] | ||
[[Category: Soundarajan, M | [[Category: Soundarajan, M]] | ||
[[Category: Sundstrom, M | [[Category: Sundstrom, M]] | ||
[[Category: Weigelt, J | [[Category: Weigelt, J]] | ||
[[Category: Regulator of g-protein signaling]] | [[Category: Regulator of g-protein signaling]] | ||
[[Category: Sgc]] | [[Category: Sgc]] | ||
[[Category: Signaling protein]] | [[Category: Signaling protein]] | ||
