2rli: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2rli]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RLI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RLI FirstGlance]. <br> | <table><tr><td colspan='2'>[[2rli]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RLI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RLI FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU1:COPPER+(I)+ION'>CU1</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU1:COPPER+(I)+ION'>CU1</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SCO2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SCO2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rli FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rli OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rli RCSB], [http://www.ebi.ac.uk/pdbsum/2rli PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rli FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rli OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rli RCSB], [http://www.ebi.ac.uk/pdbsum/2rli PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/SCO2_HUMAN SCO2_HUMAN]] Defects in SCO2 are the cause of fatal infantile cardioencephalomyopathy with cytochrome c oxidase deficiency (FIC) [MIM:[http://omim.org/entry/604377 604377]]. This disease is characterized by hypertrophic cardiomyopathy, lactic acidosis, and gliosis. Heart and skeletal muscle show reductions in cytochrome c oxidase (COX) activity, whereas liver and fibroblasts show mild COX deficiencies.<ref>PMID:10545952</ref> <ref>PMID:10749987</ref> <ref>PMID:11673586</ref> | [[http://www.uniprot.org/uniprot/SCO2_HUMAN SCO2_HUMAN]] Defects in SCO2 are the cause of fatal infantile cardioencephalomyopathy with cytochrome c oxidase deficiency (FIC) [MIM:[http://omim.org/entry/604377 604377]]. This disease is characterized by hypertrophic cardiomyopathy, lactic acidosis, and gliosis. Heart and skeletal muscle show reductions in cytochrome c oxidase (COX) activity, whereas liver and fibroblasts show mild COX deficiencies.<ref>PMID:10545952</ref> <ref>PMID:10749987</ref> <ref>PMID:11673586</ref> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Banci, L | [[Category: Banci, L]] | ||
[[Category: Bertini, I | [[Category: Bertini, I]] | ||
[[Category: Ciofi-baffoni, S | [[Category: Ciofi-baffoni, S]] | ||
[[Category: Gerothanassis, I P | [[Category: Gerothanassis, I P]] | ||
[[Category: Leontari, I | [[Category: Leontari, I]] | ||
[[Category: Martinelli, M | [[Category: Martinelli, M]] | ||
[[Category: SPINE, Structural Proteomics in Europe | [[Category: SPINE, Structural Proteomics in Europe]] | ||
[[Category: Wang, S | [[Category: Wang, S]] | ||
[[Category: Copper protein]] | [[Category: Copper protein]] | ||
[[Category: Metal transport]] | [[Category: Metal transport]] | ||
