1ic9: Difference between revisions
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|PDB= 1ic9 |SIZE=350|CAPTION= <scene name='initialview01'>1ic9</scene> | |PDB= 1ic9 |SIZE=350|CAPTION= <scene name='initialview01'>1ic9</scene> | ||
|SITE= | |SITE= | ||
|LIGAND= | |LIGAND= <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DPR:D-PROLINE'>DPR</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY=[[1icl|1ICL]], [[1ico|1ICO]] | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ic9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ic9 OCA], [http://www.ebi.ac.uk/pdbsum/1ic9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ic9 RCSB]</span> | |||
}} | }} | ||
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[[Category: three stranded antiparallel beta-sheet mini-protein motif de novo protein design]] | [[Category: three stranded antiparallel beta-sheet mini-protein motif de novo protein design]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:17:41 2008'' | ||
Revision as of 18:17, 30 March 2008
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| 1ic9 | |||||||||||||
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| Ligands: | DAL, DPR | ||||||||||||
| Related: | 1ICL, 1ICO
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
NMR SOLUTION STRUCTURE OF THE DESIGNED BETA-SHEET MINI-PROTEIN TH10AOX
Overview
Here we report the creation of a predominantly beta-structured mini-protein motif. The design target is based on the naturally occurring toxin hand (TH) motifs that are composed of four disulfide bonds and three loops that form a 'hand'. Analysis and subsequent modification of several generations of mini-proteins produced the final 29-residue mini-protein. The structured motif of this new mini-protein provides insight into the compensatory changes that result in the formation of a tightly packed hydrophobic core in a small, globular beta-structure motif. Additionally, this mini-motif represents a new, distinct surface topology for protein design and a valuable, yet compact, model system for the study of beta-sheet structure in water.
About this Structure
1IC9 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Design of a discretely folded mini-protein motif with predominantly beta-structure., Ottesen JJ, Imperiali B, Nat Struct Biol. 2001 Jun;8(6):535-9. PMID:11373623
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