2v4h: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2v4h]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V4H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V4H FirstGlance]. <br> | <table><tr><td colspan='2'>[[2v4h]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V4H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V4H FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v4h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v4h RCSB], [http://www.ebi.ac.uk/pdbsum/2v4h PDBsum]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v4h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v4h RCSB], [http://www.ebi.ac.uk/pdbsum/2v4h PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/NEMO_MOUSE NEMO_MOUSE]] Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination (By similarity).<ref>PMID:9927690</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Agou, F | [[Category: Agou, F]] | ||
[[Category: Cordier, F | [[Category: Cordier, F]] | ||
[[Category: Delepierre, M | [[Category: Delepierre, M]] | ||
[[Category: Duquerroy, S | [[Category: Duquerroy, S]] | ||
[[Category: Grubisha, O | [[Category: Grubisha, O]] | ||
[[Category: Haouz, A | [[Category: Haouz, A]] | ||
[[Category: Veron, M | [[Category: Veron, M]] | ||
[[Category: Metal-binding]] | [[Category: Metal-binding]] | ||
[[Category: Nemo - ikk gamma - nfkb pathway -darpin]] | [[Category: Nemo - ikk gamma - nfkb pathway -darpin]] | ||
[[Category: Transcription]] | [[Category: Transcription]] | ||
[[Category: Transcription regulation]] | [[Category: Transcription regulation]] | ||
