2wzl: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2wzl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mokola_virus Mokola virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WZL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WZL FirstGlance]. <br> | <table><tr><td colspan='2'>[[2wzl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mokola_virus Mokola virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WZL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WZL FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wzl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wzl RCSB], [http://www.ebi.ac.uk/pdbsum/2wzl PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wzl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wzl RCSB], [http://www.ebi.ac.uk/pdbsum/2wzl PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/PHOSP_MOKV PHOSP_MOKV]] Non catalytic polymerase cofactor and regulatory protein that plays a role in viral transcription and replication. Stabilizes the RNA polymerase L to the N-RNA template and binds the soluble protein N, preventing it from encapsidating non-genomic RNA. Also inhibits host IFN-alpha and IFN-beta signaling by binding and retaining phosphorylated STAT1 in the cytoplasm or by inhibiting the DNA binding of STAT1 in the nucleus (By similarity). | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Mokola virus]] | [[Category: Mokola virus]] | ||
[[Category: Assenberg, R | [[Category: Assenberg, R]] | ||
[[Category: Bourhy, H | [[Category: Bourhy, H]] | ||
[[Category: Delmas, O | [[Category: Delmas, O]] | ||
[[Category: Graham, S | [[Category: Graham, S]] | ||
[[Category: Grimes, J | [[Category: Grimes, J]] | ||
[[Category: Larrous, F | [[Category: Larrous, F]] | ||
[[Category: Ren, J | [[Category: Ren, J]] | ||
[[Category: Tangy, F | [[Category: Tangy, F]] | ||
[[Category: Verma, A | [[Category: Verma, A]] | ||
[[Category: Vidalain, P | [[Category: Vidalain, P]] | ||
[[Category: Chaperone]] | [[Category: Chaperone]] | ||
[[Category: Nucleoprotein]] | [[Category: Nucleoprotein]] | ||
