4p0n: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4p0n]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P0N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P0N FirstGlance]. <br> | <table><tr><td colspan='2'>[[4p0n]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P0N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P0N FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1IR:N-[CIS-3-(2-METHOXY-3H-IMIDAZO[4,5-B]PYRIDIN-3-YL)CYCLOBUTYL]-1,3-BENZOTHIAZOL-2-AMINE'>1IR</scene>, <scene name='pdbligand=1IS:N-[TRANS-3-(2-METHOXY-3H-IMIDAZO[4,5-B]PYRIDIN-3-YL)CYCLOBUTYL]-1,3-BENZOTHIAZOL-2-AMINE'>1IS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1IR:N-[CIS-3-(2-METHOXY-3H-IMIDAZO[4,5-B]PYRIDIN-3-YL)CYCLOBUTYL]-1,3-BENZOTHIAZOL-2-AMINE'>1IR</scene>, <scene name='pdbligand=1IS:N-[TRANS-3-(2-METHOXY-3H-IMIDAZO[4,5-B]PYRIDIN-3-YL)CYCLOBUTYL]-1,3-BENZOTHIAZOL-2-AMINE'>1IS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p0n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p0n RCSB], [http://www.ebi.ac.uk/pdbsum/4p0n PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p0n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p0n RCSB], [http://www.ebi.ac.uk/pdbsum/4p0n PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Chmait, S | [[Category: Chmait, S]] | ||
[[Category: Hydrolase-hydrolase inhibitor complex]] | [[Category: Hydrolase-hydrolase inhibitor complex]] | ||
