4v0p: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4v0p]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V0P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4V0P FirstGlance]. <br> | <table><tr><td colspan='2'>[[4v0p]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V0P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4V0P FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4v0p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v0p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4v0p RCSB], [http://www.ebi.ac.uk/pdbsum/4v0p PDBsum]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4v0p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v0p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4v0p RCSB], [http://www.ebi.ac.uk/pdbsum/4v0p PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/MAGA3_HUMAN MAGA3_HUMAN]] Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.<ref>PMID:20864041</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Aitkenhead, H | [[Category: Aitkenhead, H]] | ||
[[Category: Arrowsmith, C H | [[Category: Arrowsmith, C H]] | ||
[[Category: Bountra, C | [[Category: Bountra, C]] | ||
[[Category: Cooper, C D.O | [[Category: Cooper, C D.O]] | ||
[[Category: Delft, F von | [[Category: Delft, F von]] | ||
[[Category: Edwards, A | [[Category: Edwards, A]] | ||
[[Category: Gileadi, O | [[Category: Gileadi, O]] | ||
[[Category: Newman, J A | [[Category: Newman, J A]] | ||
[[Category: Pinkas, D M | [[Category: Pinkas, D M]] | ||
[[Category: Immune system]] | [[Category: Immune system]] | ||
[[Category: Mage]] | [[Category: Mage]] | ||
[[Category: Melanoma associated antigen]] | [[Category: Melanoma associated antigen]] | ||
Revision as of 11:45, 25 December 2014
Crystal structure of the MAGE homology domain of human MAGE-A3
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