1irk: Difference between revisions

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|PDB= 1irk |SIZE=350|CAPTION= <scene name='initialview01'>1irk</scene>, resolution 2.1&Aring;
|PDB= 1irk |SIZE=350|CAPTION= <scene name='initialview01'>1irk</scene>, resolution 2.1&Aring;
|SITE=  
|SITE=  
|LIGAND= <scene name='pdbligand=EMC:ETHYL MERCURY ION'>EMC</scene>
|LIGAND= <scene name='pdbligand=EMC:ETHYL+MERCURY+ION'>EMC</scene>
|ACTIVITY=  
|ACTIVITY=  
|GENE=  
|GENE=  
|DOMAIN=
|RELATEDENTRY=
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1irk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1irk OCA], [http://www.ebi.ac.uk/pdbsum/1irk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1irk RCSB]</span>
}}
}}


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==Overview==
==Overview==
The X-ray crystal structure of the tyrosine kinase domain of the human insulin receptor has been determined by multiwavelength anomalous diffraction phasing and refined to 2.1 A resolution. The structure reveals the determinants of substrate preference for tyrosine rather than serine or threonine and a novel autoinhibition mechanism whereby one of the tyrosines that is autophosphorylated in response to insulin, Tyr 1,162, is bound in the active site.
The X-ray crystal structure of the tyrosine kinase domain of the human insulin receptor has been determined by multiwavelength anomalous diffraction phasing and refined to 2.1 A resolution. The structure reveals the determinants of substrate preference for tyrosine rather than serine or threonine and a novel autoinhibition mechanism whereby one of the tyrosines that is autophosphorylated in response to insulin, Tyr 1,162, is bound in the active site.
==Disease==
Known diseases associated with this structure: Diabetes mellitus, insulin-resistant, with acanthosis nigricans OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147670 147670]], Hyperinsulinemic hypoglycemia, familial, 5 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147670 147670]], Leprechaunism OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147670 147670]], Rabson-Mendenhall syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147670 147670]]


==About this Structure==
==About this Structure==
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[[Category: Hubbard, S R.]]
[[Category: Hubbard, S R.]]
[[Category: Wei, L.]]
[[Category: Wei, L.]]
[[Category: EMC]]
[[Category: transferase (phosphotransferase)]]
[[Category: transferase (phosphotransferase)]]


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