4mn3: Difference between revisions
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mn3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mn3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mn3 RCSB], [http://www.ebi.ac.uk/pdbsum/4mn3 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mn3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mn3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mn3 RCSB], [http://www.ebi.ac.uk/pdbsum/4mn3 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/CBX7_HUMAN CBX7_HUMAN]] Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.<ref>PMID:19636380</ref> <ref>PMID:21060834</ref> <ref>PMID:21282530</ref> <ref>PMID:21047797</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
[[Category: Boulanger, M J | [[Category: Boulanger, M J]] | ||
[[Category: Chakravarthi, S | [[Category: Chakravarthi, S]] | ||
[[Category: Daze, K | [[Category: Daze, K]] | ||
[[Category: Dev, A | [[Category: Dev, A]] | ||
[[Category: Douglas, S | [[Category: Douglas, S]] | ||
[[Category: Heller, M | [[Category: Heller, M]] | ||
[[Category: Hof, F | [[Category: Hof, F]] | ||
[[Category: Peng, F | [[Category: Peng, F]] | ||
[[Category: Quon, T | [[Category: Quon, T]] | ||
[[Category: Wulff, J | [[Category: Wulff, J]] | ||
[[Category: Chromobox domain 7]] | [[Category: Chromobox domain 7]] | ||
[[Category: Transcription regulator]] | [[Category: Transcription regulator]] | ||
