4wib: Difference between revisions

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'''Unreleased structure'''
==Crystal structure of Magnesium transporter MgtE==
<StructureSection load='4wib' size='340' side='right' caption='[[4wib]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4wib]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WIB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WIB FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wib FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wib OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wib RCSB], [http://www.ebi.ac.uk/pdbsum/4wib PDBsum]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Magnesium is the most abundant divalent cation in living cells and is crucial to several biological processes. MgtE is a Mg(2+) channel distributed in all domains of life that contributes to the maintenance of cellular Mg(2+) homeostasis. Here we report the high-resolution crystal structures of the transmembrane domain of MgtE, bound to Mg(2+), Mn(2+) and Ca(2+). The high-resolution Mg(2+)-bound crystal structure clearly visualized the hydrated Mg(2+) ion within its selectivity filter. Based on those structures and biochemical analyses, we propose a cation selectivity mechanism for MgtE in which the geometry of the hydration shell of the fully hydrated Mg(2+) ion is recognized by the side-chain carboxylate groups in the selectivity filter. This is in contrast to the K(+)-selective filter of KcsA, which recognizes a dehydrated K(+) ion. Our results further revealed a cation-binding site on the periplasmic side, which regulate channel opening and prevents conduction of near-cognate cations.


The entry 4wib is ON HOLD
Structural basis for ion selectivity revealed by high-resolution crystal structure of Mg(2+) channel MgtE.,Takeda H, Hattori M, Nishizawa T, Yamashita K, Shah ST, Caffrey M, Maturana AD, Ishitani R, Nureki O Nat Commun. 2014 Nov 4;5:5374. doi: 10.1038/ncomms6374. PMID:25367295<ref>PMID:25367295</ref>


Authors: Takeda, H., Hattori, M., Nishizawa, T., Yamashita, K., Shah, S.T.A., Caffrey, M., Maturana, A.D., Ishitani, R., Nureki, O.
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
Description: Crystal structure of Magnesium transporter MgtE
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Caffrey, M]]
[[Category: Hattori, M]]
[[Category: Ishitani, R]]
[[Category: Maturana, A D]]
[[Category: Nishizawa, T]]
[[Category: Nureki, O]]
[[Category: Shah, S T.A]]
[[Category: Takeda, H]]
[[Category: Yamashita, K]]
[[Category: Channel]]
[[Category: Magnesium]]
[[Category: Transporter]]
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