2w15: Difference between revisions
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w15 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w15 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w15 RCSB], [http://www.ebi.ac.uk/pdbsum/2w15 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w15 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w15 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w15 RCSB], [http://www.ebi.ac.uk/pdbsum/2w15 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/VMBP1_BOTAS VMBP1_BOTAS]] Zinc metalloprotease that exhibits a weak hemorrhagic activity (with a minimum hemorrhagic dose of 20 ug by intradermal and intramuscular injection into mice). The basal membrane components collagen (all chains of type IV) (COL4A4), laminin and nidogen are all degraded by this toxin (PubMed:23385358). Rapidly degrades the Aalpha-chain (FGA) of fibrinogen, and later on, degrades the Bbeta-chain (FGB) of fibrinogen (PubMed:7778126). Also activates the complement system, and induces rat neutrophil chemotaxis (PubMed:11200361). Induces edema in mouse food pad and a mild myotoxicity (PubMed:7778126).<ref>PMID:7778126</ref> <ref>PMID:11200361</ref> <ref>PMID:20600221</ref> <ref>PMID:23385358</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Bothrops asper]] | [[Category: Bothrops asper]] | ||
[[Category: Gutierrez, J M | [[Category: Gutierrez, J M]] | ||
[[Category: Lingott, T J | [[Category: Lingott, T J]] | ||
[[Category: Merfort, I | [[Category: Merfort, I]] | ||
[[Category: Schleberger, C | [[Category: Schleberger, C]] | ||
[[Category: Adamalysin]] | [[Category: Adamalysin]] | ||
[[Category: Alpha-beta protein]] | [[Category: Alpha-beta protein]] | ||
