VP24: Difference between revisions
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== Introduction == | == Introduction == | ||
VP24 is a protein present in | VP24 is a protein present in the ebola and marburg viruses, both of which are members of Filoviridae. Presently there are five strains of ebola: Sudan, Reston, Zire, Bundibugyo, and Taï Forest, each with minor differences in VP24 sequences(3). The marburg virus has only one strain. | ||
== Function == | == Function == | ||
In Ebola | |||
In a normal immune response interferons (IFN) are produced to alert surrounding cells of the presence of a pathogen. This response activates STAT1, which increases production of immune fighting genes in cells, by phosphorylation. STAT1 is brought to the nucleus by karyopherin α proteins. Ebola protein VP24 binds to karyopherin α1, α5, and α6, making it unable to transport the P-STAT1 to the nucleus. The immune response in cells is then greatly weakened. | In a normal immune response interferons (IFN) are produced to alert surrounding cells of the presence of a pathogen. This response activates STAT1, which increases production of immune fighting genes in cells, by phosphorylation. STAT1 is brought to the nucleus by karyopherin α proteins. Ebola protein VP24 binds to karyopherin α1, α5, and α6, making it unable to transport the P-STAT1 to the nucleus. The immune response in cells is then greatly weakened. | ||
In Marburg | |||
== Disease == | == Disease == | ||
