Telomerase: Difference between revisions

Line 4:

== History ==

In the 1930s, Barbara McClintock was the first to point out that the ends of chromosomes are somewhat different. Over forty years later, Olovnikov (1973) and Watson (1972) indicated an 'end replication problem' in which the lagging strand of DNA cannot be fully copied (Blackburn 2010). This concept led to a waterfall of studies and information vitally important to cellular regulation. In 1978, acclaimed chemist and front-runner in telomerase studies, Elizabeth H. Blackburn, discovered the telomere in ''Tetrahymena thermophila''. By 1985, Blackburn and Carol Greider noted the enzymatic activity that created the telomeric sequences, and in 1987, the two women officially identified the telomerase as a ribonucleaoprotein with an essential RNA and and protein component (Corey 2009).

In the 1930s, Barbara McClintock was the first to point out that the ends of chromosomes are somewhat different. Over forty years later, Olovnikov (1973) and Watson (1972) indicated an 'end replication problem' in which the lagging strand of DNA cannot be fully copied (Blackburn 2010). This concept led to a waterfall of studies and information vitally important to cellular regulation. In 1978, acclaimed chemist and front-runner in telomerase studies, Elizabeth H. Blackburn, discovered the telomere in ''Tetrahymena thermophila''. By 1985, Blackburn and Carol Greider noted the enzymatic activity that created the telomeric sequences, and in 1987, the two women officially identified the telomerase as a ribonucleaoprotein with an essential RNA and and protein component (Corey 2009). Elizabeth Blackburn, Carol Greider, and Jack Szostak won the 2009 Noble Prize in Physiology or Medicine for their lifetime work regarding the telomere and telomerase.

Since 1987, the study of the telomerase has exploded. [[Image:Figure1.jpg]]

== Structure ==

Telomerase: Difference between revisions

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 4: / Line 4: @@
 == History ==
-In the 1930s, Barbara McClintock was the first to point out that the ends of chromosomes are somewhat different. Over forty years later, Olovnikov (1973) and Watson (1972) indicated an 'end replication problem' in which the lagging strand of DNA cannot be fully copied (Blackburn 2010). This concept led to a waterfall of studies and information vitally important to cellular regulation. In 1978, acclaimed chemist and front-runner in telomerase studies, Elizabeth H. Blackburn, discovered the telomere in ''Tetrahymena thermophila''. By 1985, Blackburn and Carol Greider noted the enzymatic activity that created the telomeric sequences, and in 1987, the two women officially identified the telomerase as a ribonucleaoprotein with an essential RNA and and protein component (Corey 2009).
+In the 1930s, Barbara McClintock was the first to point out that the ends of chromosomes are somewhat different. Over forty years later, Olovnikov (1973) and Watson (1972) indicated an 'end replication problem' in which the lagging strand of DNA cannot be fully copied (Blackburn 2010). This concept led to a waterfall of studies and information vitally important to cellular regulation. In 1978, acclaimed chemist and front-runner in telomerase studies, Elizabeth H. Blackburn, discovered the telomere in ''Tetrahymena thermophila''. By 1985, Blackburn and Carol Greider noted the enzymatic activity that created the telomeric sequences, and in 1987, the two women officially identified the telomerase as a ribonucleaoprotein with an essential RNA and and protein component (Corey 2009). Elizabeth Blackburn, Carol Greider, and Jack Szostak won the 2009 Noble Prize in Physiology or Medicine for their lifetime work regarding the telomere and telomerase.
+Since 1987, the study of the telomerase has exploded. [[Image:Figure1.jpg]]
 == Structure ==