2dbh: Difference between revisions
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dbh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dbh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2dbh RCSB], [http://www.ebi.ac.uk/pdbsum/2dbh PDBsum], [http://www.topsan.org/Proteins/RSGI/2dbh TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dbh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dbh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2dbh RCSB], [http://www.ebi.ac.uk/pdbsum/2dbh PDBsum], [http://www.topsan.org/Proteins/RSGI/2dbh TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/TNR21_HUMAN TNR21_HUMAN]] May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). | |||
==See Also== | ==See Also== | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Inoue, M | [[Category: Inoue, M]] | ||
[[Category: Kigawa, T | [[Category: Kigawa, T]] | ||
[[Category: Koshiba, S | [[Category: Koshiba, S]] | ||
[[Category: | [[Category: Structural genomic]] | ||
[[Category: Saito, K | [[Category: Saito, K]] | ||
[[Category: Yokoyama, S | [[Category: Yokoyama, S]] | ||
[[Category: Apoptosis]] | [[Category: Apoptosis]] | ||
[[Category: National project on protein structural and functional analyse]] | [[Category: National project on protein structural and functional analyse]] | ||
[[Category: Nf-kappab]] | [[Category: Nf-kappab]] | ||
[[Category: Nppsfa]] | [[Category: Nppsfa]] | ||
[[Category: Rsgi]] | [[Category: Rsgi]] | ||
[[Category: Signaling protein]] | [[Category: Signaling protein]] | ||
[[Category: Tnf receptor superfamily]] | [[Category: Tnf receptor superfamily]] | ||
