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VP24 is crucial for proper functioni of the viral nucleoprotein | VP24 is crucial for proper functioni of the viral nucleoprotein | ||
Marburg | <scene name='60/602719/Marburg_vp24/1'>Marburg Structure</scene> | ||
IntroductionVP24 is a protein present in the ebola and marburg viruses, both of which are members of Filoviridae family. Presently there are five strains of ebola: Sudan, Reston, Zire, Bundibugyo, and Taï Forest, each with minor differences in VP24 sequences(3). The marburg virus has only one strain. FunctionEbola In a normal immune response interferons (IFN) are produced to alert surrounding cells of the presence of a pathogen. This response activates STAT1, which increases production of immune fighting genes in cells, by phosphorylation. STAT1 is brought to the nucleus by karyopherin α proteins. Ebola protein VP24 binds to karyopherin α1, α5, and α6, making it unable to transport the P-STAT1 to the nucleus. As a result the immune response in cells is then greatly weakened. The Reston strain is not immuno_____, unlike the other four. Marburg
Structural CharacteristicsThe ebola and marburg versions are 30% identical. Ebola VP24 is crucial for proper functioni of the viral nucleoprotein
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This page was last modified 17:41, 13 October 2014.