VP24: Difference between revisions
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In a normal immune response interferons (IFN) are produced to alert surrounding cells of the presence of a pathogen. This response activates STAT1, which increases production of immune fighting genes in cells, by phosphorylation. STAT1 is brought to the nucleus by karyopherin α proteins. Ebola protein VP24 binds to karyopherin α1, α5, and α6, making it unable to transport the P-STAT1 to the nucleus. As a result the immune response in cells is then greatly weakened. The Reston strain is the only strain that is not dangerous to humans. | In a normal immune response interferons (IFN) are produced to alert surrounding cells of the presence of a pathogen. This response activates STAT1, which increases production of immune fighting genes in cells, by phosphorylation. STAT1 is brought to the nucleus by karyopherin α proteins. Ebola protein VP24 binds to karyopherin α1, α5, and α6, making it unable to transport the P-STAT1 to the nucleus. As a result the immune response in cells is then greatly weakened. The Reston strain is the only strain that is not dangerous to humans. | ||
VP24 also is important for the structure of the virus. The structure of the nucleocapsid helix of Ebola | |||
'''Marburg''' | '''Marburg''' | ||
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== Structural Characteristics == | == Structural Characteristics == | ||
The | The Ebola and Marburg VP24 proteins are 30% identical. They share a similar pyramidal shape, as well as a few structures. Both viruses have two highly conserved pockets underneath the "pyramid's" base. Additionally, the N termini of Ebola (Zaire) and the Marburg virus are very similar. | ||
<scene name='60/602719/Reston_vp24/1'>Ebola Structure</scene> (Reston) | <scene name='60/602719/Reston_vp24/1'>Ebola Structure</scene> (Reston) | ||
