1fcw

TRNA POSITIONS DURING THE ELONGATION CYCLE

spinqualitylabelsall models 1fcw, resolution 17.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1fcw is a 5 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. NonStd Res: 1MA, 2MG, 5MC, 5MU, 7MG, H2U, M2G, OMC, OMG, PSU, YG Related: 486d Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed Three-dimensional cryomaps have been reconstructed for tRNA-ribosome complexes in pre- and posttranslocational states at 17-A resolution. The positions of tRNAs in the A and P sites in the pretranslocational complexes and in the P and E sites in the posttranslocational complexes have been determined. Of these, the P-site tRNA position is the same as seen earlier in the initiation-like fMet-tRNA(f)(Met)-ribosome complex, where it was visualized with high accuracy. Now, the positions of the A- and E-site tRNAs are determined with similar accuracy. The positions of the CCA end of the tRNAs at the A site are different before and after peptide bond formation. The relative positions of anticodons of P- and E-site tRNAs in the posttranslocational state are such that a codon-anticodon interaction at the E site appears feasible. Visualization of tRNA movements on the Escherichia coli 70S ribosome during the elongation cycle.,Agrawal RK, Spahn CM, Penczek P, Grassucci RA, Nierhaus KH, Frank J J Cell Biol. 2000 Aug 7;150(3):447-60. PMID:10931859 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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