4tyl: Difference between revisions

Line 1:

'''~~Unreleased~~ structure'''

==Fragment-Based Screening of the Bromodomain of ATAD2==

== Structural highlights ==

<table><tr><td colspan='2'>[[4tyl]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TYL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TYL FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=39O:5-AMINO-1,3,6-TRIMETHYL-1,3-DIHYDRO-2H-BENZIMIDAZOL-2-ONE'>39O</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4tz2|4tz2]], [[4tz8|4tz8]]</td></tr>

<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosinetriphosphatase Adenosinetriphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.3 3.6.1.3] </span></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tyl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tyl RCSB], [http://www.ebi.ac.uk/pdbsum/4tyl PDBsum]</span></td></tr>

</table>

== Publication Abstract from PubMed ==

Cellular and genetic evidence suggest that inhibition of ATAD2 could be a useful strategy to treat several types of cancer. To discover small molecule inhibitors of the bromodomain of ATAD2, we used a fragment-based approach. Fragment hits were identified using NMR spectroscopy, and ATAD2 was crystallized with three of the hits identified in the fragment screen.

~~The entry 4tyl is ON HOLD until Paper Publication~~

Fragment-based screening of the bromodomain of ATAD2.,Harner MJ, Chauder BA, Phan J, Fesik SW J Med Chem. 2014 Oct 14. PMID:25314628<ref>PMID:25314628</ref>

~~Authors: Harner~~, M.J., Chauder, B.A., ~~Phan~~, J., ~~Fesik, S.W~~.

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

</div>

~~Description~~:

== References ==

__TOC__

</StructureSection>

[[Category: Adenosinetriphosphatase]]

[[Category: Chauder, B A.]]

[[Category: Fesik, S W.]]

[[Category: Harner, M J.]]

[[Category: Phan, J.]]

[[Category: Bromodomain]]

[[Category: Hydrolase-hydrolase inhibitor complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Fragment-Based Screening of the Bromodomain of ATAD2==
+<StructureSection load='4tyl' size='340' side='right' caption='[[4tyl]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4tyl]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TYL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TYL FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=39O:5-AMINO-1,3,6-TRIMETHYL-1,3-DIHYDRO-2H-BENZIMIDAZOL-2-ONE'>39O</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4tz2|4tz2]], [[4tz8|4tz8]]</td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosinetriphosphatase Adenosinetriphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.3 3.6.1.3] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tyl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tyl RCSB], [http://www.ebi.ac.uk/pdbsum/4tyl PDBsum]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Cellular and genetic evidence suggest that inhibition of ATAD2 could be a useful strategy to treat several types of cancer. To discover small molecule inhibitors of the bromodomain of ATAD2, we used a fragment-based approach. Fragment hits were identified using NMR spectroscopy, and ATAD2 was crystallized with three of the hits identified in the fragment screen.
-The entry 4tyl is ON HOLD  until Paper Publication
+Fragment-based screening of the bromodomain of ATAD2.,Harner MJ, Chauder BA, Phan J, Fesik SW J Med Chem. 2014 Oct 14. PMID:25314628<ref>PMID:25314628</ref>
-Authors: Harner, M.J., Chauder, B.A., Phan, J., Fesik, S.W.
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-Description:
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Adenosinetriphosphatase]]
+[[Category: Chauder, B A.]]
+[[Category: Fesik, S W.]]
+[[Category: Harner, M J.]]
+[[Category: Phan, J.]]
+[[Category: Bromodomain]]
+[[Category: Hydrolase-hydrolase inhibitor complex]]