1jx6: Difference between revisions
No edit summary |
No edit summary |
||
| Line 4: | Line 4: | ||
|PDB= 1jx6 |SIZE=350|CAPTION= <scene name='initialview01'>1jx6</scene>, resolution 1.50Å | |PDB= 1jx6 |SIZE=350|CAPTION= <scene name='initialview01'>1jx6</scene>, resolution 1.50Å | ||
|SITE= | |SITE= | ||
|LIGAND= | |LIGAND= <scene name='pdbligand=AI2:3A-METHYL-5,6-DIHYDRO-FURO[2,3-D][1,3,2]DIOXABOROLE-2,2,6,6A-TETRAOL'>AI2</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= LUXP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=669 Vibrio harveyi]) | |GENE= LUXP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=669 Vibrio harveyi]) | ||
|DOMAIN= | |||
|RELATEDENTRY= | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jx6 OCA], [http://www.ebi.ac.uk/pdbsum/1jx6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jx6 RCSB]</span> | |||
}} | }} | ||
| Line 29: | Line 32: | ||
[[Category: Potier, N.]] | [[Category: Potier, N.]] | ||
[[Category: Schauder, S.]] | [[Category: Schauder, S.]] | ||
[[Category: protein-ligand complex]] | [[Category: protein-ligand complex]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:40:18 2008'' | ||
Revision as of 18:40, 30 March 2008
| |||||||||||||
| 1jx6, resolution 1.50Å | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ligands: | AI2, CA | ||||||||||||
| Gene: | LUXP (Vibrio harveyi) | ||||||||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
CRYSTAL STRUCTURE OF LUXP FROM VIBRIO HARVEYI COMPLEXED WITH AUTOINDUCER-2
Overview
Cell-cell communication in bacteria is accomplished through the exchange of extracellular signalling molecules called autoinducers. This process, termed quorum sensing, allows bacterial populations to coordinate gene expression. Community cooperation probably enhances the effectiveness of processes such as bioluminescence, virulence factor expression, antibiotic production and biofilm development. Unlike other autoinducers, which are specific to a particular species of bacteria, a recently discovered autoinducer (AI-2) is produced by a large number of bacterial species. AI-2 has been proposed to serve as a 'universal' signal for inter-species communication. The chemical identity of AI-2 has, however, proved elusive. Here we present the crystal structure of an AI-2 sensor protein, LuxP, in a complex with autoinducer. The bound ligand is a furanosyl borate diester that bears no resemblance to previously characterized autoinducers. Our findings suggest that addition of naturally occurring borate to an AI-2 precursor generates active AI-2. Furthermore, they indicate a potential biological role for boron, an element required by a number of organisms but for unknown reasons.
About this Structure
1JX6 is a Single protein structure of sequence from Vibrio harveyi. Full crystallographic information is available from OCA.
Reference
Structural identification of a bacterial quorum-sensing signal containing boron., Chen X, Schauder S, Potier N, Van Dorsselaer A, Pelczer I, Bassler BL, Hughson FM, Nature. 2002 Jan 31;415(6871):545-9. PMID:11823863
Page seeded by OCA on Sun Mar 30 21:40:18 2008
