2xzt: Difference between revisions
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xzt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xzt RCSB], [http://www.ebi.ac.uk/pdbsum/2xzt PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xzt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xzt RCSB], [http://www.ebi.ac.uk/pdbsum/2xzt PDBsum]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/CASP3_HUMAN CASP3_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.<ref>PMID:7596430</ref> <ref>PMID:21357690</ref> | |||
==See Also== | ==See Also== | ||
*[[Caspase|Caspase]] | *[[Caspase|Caspase]] | ||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Unidentified]] | [[Category: Unidentified]] | ||
[[Category: Barandun, J | [[Category: Barandun, J]] | ||
[[Category: Grutter, M G | [[Category: Grutter, M G]] | ||
[[Category: Mittl, P | [[Category: Mittl, P]] | ||
[[Category: Schroeder, T | [[Category: Schroeder, T]] | ||
[[Category: Ankyrin repeat protein]] | [[Category: Ankyrin repeat protein]] | ||
[[Category: Apoptosis]] | [[Category: Apoptosis]] | ||
