4wj7: Difference between revisions

Line 1:

'''~~Unreleased~~ structure'''

==CCM2 PTB domain in complex with KRIT1 NPxY/F3==

The entry ~~4wj7~~ is ~~ON HOLD until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4wj7]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WJ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WJ7 FirstGlance]. <br>

~~Authors~~: Fisher, O.S., Liu, W~~., Zhang, R.,~~ Stiegler, A.L., ~~Boggon, T.J.~~

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wj7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wj7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wj7 RCSB], [http://www.ebi.ac.uk/pdbsum/4wj7 PDBsum]</span></td></tr>

</table>

~~Description~~:

== Disease ==

[[http://www.uniprot.org/uniprot/CCM2_HUMAN CCM2_HUMAN]] Hereditary cerebral cavernous malformation. The disease is caused by mutations affecting the gene represented in this entry.

== Function ==

[[http://www.uniprot.org/uniprot/CCM2_HUMAN CCM2_HUMAN]] Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity).

__TOC__

</StructureSection>

[[Category: Boggon, T J]]

[[Category: Fisher, O S]]

[[Category: Liu, W]]

[[Category: Stiegler, A L]]

[[Category: Zhang, R]]

[[Category: Complex]]

[[Category: Npxy motif]]

[[Category: Ptb domain]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==CCM2 PTB domain in complex with KRIT1 NPxY/F3==
+<StructureSection load='4wj7' size='340' side='right' caption='[[4wj7]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
-The entry 4wj7 is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4wj7]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WJ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WJ7 FirstGlance]. <br>
-Authors: Fisher, O.S., Liu, W., Zhang, R., Stiegler, A.L., Boggon, T.J.
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wj7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wj7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wj7 RCSB], [http://www.ebi.ac.uk/pdbsum/4wj7 PDBsum]</span></td></tr>
+</table>
-Description:
+== Disease ==
+[[http://www.uniprot.org/uniprot/CCM2_HUMAN CCM2_HUMAN]] Hereditary cerebral cavernous malformation. The disease is caused by mutations affecting the gene represented in this entry.
+== Function ==
+[[http://www.uniprot.org/uniprot/CCM2_HUMAN CCM2_HUMAN]] Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity).
+__TOC__
+</StructureSection>
+[[Category: Boggon, T J]]
+[[Category: Fisher, O S]]
+[[Category: Liu, W]]
+[[Category: Stiegler, A L]]
+[[Category: Zhang, R]]
+[[Category: Complex]]
+[[Category: Npxy motif]]
+[[Category: Ptb domain]]