1k3k: Difference between revisions
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k3k OCA], [http://www.ebi.ac.uk/pdbsum/1k3k PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1k3k RCSB]</span> | |||
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==About this Structure== | ==About this Structure== | ||
1K3K is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ | 1K3K is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_8 Human herpesvirus 8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K3K OCA]. | ||
==Reference== | ==Reference== | ||
Solution structure of a Bcl-2 homolog from Kaposi sarcoma virus., Huang Q, Petros AM, Virgin HW, Fesik SW, Olejniczak ET, Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3428-33. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11904405 11904405] | Solution structure of a Bcl-2 homolog from Kaposi sarcoma virus., Huang Q, Petros AM, Virgin HW, Fesik SW, Olejniczak ET, Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3428-33. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11904405 11904405] | ||
[[Category: Human herpesvirus | [[Category: Human herpesvirus 8]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Fesik, S W.]] | [[Category: Fesik, S W.]] | ||
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[[Category: solution structure]] | [[Category: solution structure]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:42:53 2008'' | ||
Revision as of 18:42, 30 March 2008
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Solution Structure of a Bcl-2 Homolog from Kaposi's Sarcoma Virus
Overview
Kaposi sarcoma-associated herpes virus (KSHV) contains a gene that has functional and sequence homology to the apoptotic Bcl-2 family of proteins [Sarid, R., Sato, T., Bohenzky, R. A., Russo, J. J. & Chang, Y. (1997) Nat. Med. 3, 293-298]. The viral Bcl-2 protein promotes survival of infected cells and may contribute to the development of Kaposi sarcoma tumors [Boshoff, C. & Chang, Y. (2001) Annu. Rev. Med. 52, 453-470]. Here we describe the solution structure of the viral Bcl-2 homolog from KSHV. Comparison of the KSHV Bcl-2 structure to that of Bcl-2 and Bcl-x(L) shows that although the overall fold is the same, there are key differences in the lengths of the helices and loops. Binding studies on peptides derived from the Bcl-2 homology region 3 of proapoptotic family members indicate that the specificity of the viral protein is very different from what was previously observed for Bcl-x(L) and Bcl-2, suggesting that the viral protein has evolved to have a different mechanism of action than the host proteins.
About this Structure
1K3K is a Single protein structure of sequence from Human herpesvirus 8. Full crystallographic information is available from OCA.
Reference
Solution structure of a Bcl-2 homolog from Kaposi sarcoma virus., Huang Q, Petros AM, Virgin HW, Fesik SW, Olejniczak ET, Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3428-33. PMID:11904405
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