2mg0: Difference between revisions
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mg0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mg0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mg0 RCSB], [http://www.ebi.ac.uk/pdbsum/2mg0 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mg0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mg0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mg0 RCSB], [http://www.ebi.ac.uk/pdbsum/2mg0 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/PPAP_HUMAN PPAP_HUMAN]] A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma.<ref>PMID:15280042</ref> <ref>PMID:18083097</ref> <ref>PMID:19403677</ref> <ref>PMID:20498373</ref> Isoform 2: the cellular form also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor. Acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling.<ref>PMID:15280042</ref> <ref>PMID:18083097</ref> <ref>PMID:19403677</ref> <ref>PMID:20498373</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Antzutkin, O | [[Category: Antzutkin, O]] | ||
[[Category: Blokhin, D | [[Category: Blokhin, D]] | ||
[[Category: Filippov, A | [[Category: Filippov, A]] | ||
[[Category: Vklochkov, V | [[Category: Vklochkov, V]] | ||
[[Category: Hiv]] | [[Category: Hiv]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Pap]] | [[Category: Pap]] | ||
Revision as of 16:42, 25 December 2014
PAP262-270 in SDS micelles
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