4ri0: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 6: | Line 6: | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ri0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ri0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ri0 RCSB], [http://www.ebi.ac.uk/pdbsum/4ri0 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ri0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ri0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ri0 RCSB], [http://www.ebi.ac.uk/pdbsum/4ri0 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/HTRA3_HUMAN HTRA3_HUMAN]] Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans (By similarity). May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization.<ref>PMID:21321049</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Glaza, P | [[Category: Glaza, P]] | ||
[[Category: Joachimiak, A | [[Category: Joachimiak, A]] | ||
[[Category: Lipinska, B | [[Category: Lipinska, B]] | ||
[[Category: | [[Category: Structural genomic]] | ||
[[Category: Osipiuk, J | [[Category: Osipiuk, J]] | ||
[[Category: Wenta, T | [[Category: Wenta, T]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Mcsg]] | [[Category: Mcsg]] | ||
[[Category: National science center - poland]] | [[Category: National science center - poland]] | ||
[[Category: Protease]] | [[Category: Protease]] | ||
[[Category: Psi-biology]] | [[Category: Psi-biology]] | ||
