2yja: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 8: | Line 8: | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yja OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yja RCSB], [http://www.ebi.ac.uk/pdbsum/2yja PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yja OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yja RCSB], [http://www.ebi.ac.uk/pdbsum/2yja PDBsum]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/ESR1_HUMAN ESR1_HUMAN]] Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Isoform 3 is involved in activation of NOS3 and endothelial nitric oxide production. Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full length receptor. Isoform 3 can bind to ERE and inhibit isoform 1.<ref>PMID:7651415</ref> <ref>PMID:10970861</ref> <ref>PMID:9328340</ref> <ref>PMID:10681512</ref> <ref>PMID:10816575</ref> <ref>PMID:11477071</ref> <ref>PMID:11682626</ref> <ref>PMID:15078875</ref> <ref>PMID:16043358</ref> <ref>PMID:15891768</ref> <ref>PMID:16684779</ref> <ref>PMID:18247370</ref> <ref>PMID:17932106</ref> <ref>PMID:19350539</ref> <ref>PMID:20705611</ref> <ref>PMID:21937726</ref> <ref>PMID:21330404</ref> <ref>PMID:22083956</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 16: | Line 18: | ||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
==See Also== | |||
*[[Estrogen receptor|Estrogen receptor]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
| Line 21: | Line 26: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Bazin, R | [[Category: Bazin, R]] | ||
[[Category: Bent, A | [[Category: Bent, A]] | ||
[[Category: Brown, D G | [[Category: Brown, D G]] | ||
[[Category: Davies, N L | [[Category: Davies, N L]] | ||
[[Category: Irving, S L | [[Category: Irving, S L]] | ||
[[Category: Moore, R | [[Category: Moore, R]] | ||
[[Category: Pannifer, A D | [[Category: Pannifer, A D]] | ||
[[Category: Phillips, C | [[Category: Phillips, C]] | ||
[[Category: Pickford, A R | [[Category: Pickford, A R]] | ||
[[Category: Roberts, L R | [[Category: Roberts, L R]] | ||
[[Category: Schade, M | [[Category: Schade, M]] | ||
[[Category: Scott, A | [[Category: Scott, A]] | ||
[[Category: Xu, B | [[Category: Xu, B]] | ||
[[Category: Hormone receptor-peptide complex]] | [[Category: Hormone receptor-peptide complex]] | ||
