Retroviral Integrase: Difference between revisions
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<StructureSection load=1k6y size='450' side='right' scene='' caption=''> | <StructureSection load=1k6y size='450' side='right' scene='' caption='N-terminal and core domain of HIV-1 integrase (PDB code [[1k6y]])'> | ||
[[Image:3l2q.png|left|200px|thumb|Crystal Structure of Integrase [[3l2q]]]] | [[Image:3l2q.png|left|200px|thumb|Crystal Structure of Integrase [[3l2q]]]] | ||
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
{{#tree:id=OrganizedByTopic|openlevels=0| | |||
*Human spumaretrovirus integrase | |||
[[3os0]], [[3os1]], [[3os2]], [[3oy9]], [[3l2q]], [[3l2r]] – IN + DNA – human spumaretrovirus<br /> | **[[3os0]], [[3os1]], [[3os2]], [[3oy9]], [[3l2q]], [[3l2r]] – IN + DNA – human spumaretrovirus<br /> | ||
[[3oyb]], [[3oyc]], [[3oyd]], [[3oye]], [[3oyf]], [[3oyg]], [[3oyh]], [[3oyi]], [[3oyj]], [[3oyk]], [[3oyl]], [[3oym]], [[3oyn]], [[3oya]], [[3l2u]], [[3l2v]], [[3l2w]] – IN + DNA + inhibitor<br /> | **[[3oyb]], [[3oyc]], [[3oyd]], [[3oye]], [[3oyf]], [[3oyg]], [[3oyh]], [[3oyi]], [[3oyj]], [[3oyk]], [[3oyl]], [[3oym]], [[3oyn]], [[3oya]], [[3l2u]], [[3l2v]], [[3l2w]] – IN + DNA + inhibitor<br /> | ||
[[2x6n]], [[2x6s]], [[2x74]], [[2x78]], [[3dlr]] - IN catalytic core domain | **[[2x6n]], [[2x6s]], [[2x74]], [[2x78]], [[3dlr]] - IN catalytic core domain | ||
*Bovine immunodeficiency virus integrase | |||
[[3kkr]], [[3kks]] – IN catalytic core domain – BIV | **[[3kkr]], [[3kks]] – IN catalytic core domain – BIV | ||
*Human immunodeficiency virus 1 integrase | |||
[[3lpt]], [[3lpu]], [[3l3u]], [[1exq]], [[1b92]], [[1b9d]], [[1b9f]], [[1bi4]], [[1bhl]], [[1bl3]], [[1bis]], [[1biu]], [[1biz]], [[2itg]], [[3zcm]] - IN catalytic core domain (mutant) – HIV-1<br /> | **[[3lpt]], [[3lpu]], [[3l3u]], [[1exq]], [[1b92]], [[1b9d]], [[1b9f]], [[1bi4]], [[1bhl]], [[1bl3]], [[1bis]], [[1biu]], [[1biz]], [[2itg]], [[3zcm]] - IN catalytic core domain (mutant) – HIV-1<br /> | ||
[[3l3v ]]- IN catalytic core domain (mutant) + sucrose<br /> | **[[3l3v ]]- IN catalytic core domain (mutant) + sucrose<br /> | ||
[[1hyv]], [[1hyz]], [[1qs4]] - IN N-terminal + inhibitor<br /> | **[[1hyv]], [[1hyz]], [[1qs4]] - IN N-terminal + inhibitor<br /> | ||
[[1k6y]] - IN N-terminal + catalytic core domain<br /> | **[[1k6y]] - IN N-terminal + catalytic core domain<br /> | ||
[[1itg]] - IN catalytic core domain<br /> | **[[1itg]] - IN catalytic core domain<br /> | ||
[[1wje]], [[1wjf]] - IN N-terminal zinc-binding domain (mutant) – NMR<br /> | **[[1wje]], [[1wjf]] - IN N-terminal zinc-binding domain (mutant) – NMR<br /> | ||
[[1wja]], [[1wjb]], [[1wjc]], [[1wjd]] - IN N-terminal zinc-binding domain<br /> | **[[1wja]], [[1wjb]], [[1wjc]], [[1wjd]] - IN N-terminal zinc-binding domain<br /> | ||
[[1ex4]] - IN C-terminal DBD + catalytic core domain (mutant)<br /> | **[[1ex4]] - IN C-terminal DBD + catalytic core domain (mutant)<br /> | ||
[[1ihv]], [[1ihw]] – IN DBD - NMR<br /> | **[[1ihv]], [[1ihw]] – IN DBD - NMR<br /> | ||
[[1qmc]] – IN DBD - NMR<br /> | **[[1qmc]] – IN DBD - NMR<br /> | ||
[[2b4j]], [[3av9]], [[3ava]], [[3avb]], [[3avc]], [[3avf]], [[3avg]], [[3avh]], [[3avi]], [[3avj]], [[3avk]], [[3avl]], [[3avm]], [[3avn]] - IN (mutant) + lens epithelium-derived growth factor <br /> | **[[2b4j]], [[3av9]], [[3ava]], [[3avb]], [[3avc]], [[3avf]], [[3avg]], [[3avh]], [[3avi]], [[3avj]], [[3avk]], [[3avl]], [[3avm]], [[3avn]] - IN (mutant) + lens epithelium-derived growth factor <br /> | ||
[[3nf6]], [[3nf7]], [[3nf8]], [[3nf9]], [[3nfa]], [[4e1m]], [[4e1n]], [[4cj4]], [[4jlh]] - IN core domain (mutant) + inhibitor<br /> | **[[3nf6]], [[3nf7]], [[3nf8]], [[3nf9]], [[3nfa]], [[4e1m]], [[4e1n]], [[4cj4]], [[4jlh]] - IN core domain (mutant) + inhibitor<br /> | ||
*Human immunodeficiency virus 2 integrase | |||
[[3f9k]] - IN N-terminal + catalytic core domain + LEDGF IBD – HIV-2<br /> | **[[3f9k]] - IN N-terminal + catalytic core domain + LEDGF IBD – HIV-2<br /> | ||
[[1e0e]] - IN N-terminal – NMR | **[[1e0e]] - IN N-terminal – NMR | ||
*Moloney murine leukemia virus integrase | |||
[[3nnq]] – IN N-terminal – MOMLV | **[[3nnq]] – IN N-terminal – MOMLV | ||
*Maedi Visna virus integrase | |||
[[3hpg]], [[3hph]] – IN N-terminal + catalytic core domain + LEDGF IBD – MVV | **[[3hpg]], [[3hph]] – IN N-terminal + catalytic core domain + LEDGF IBD – MVV | ||
*Simian immunodeficiency virus integrase | |||
[[1c6v]] – IN catalytic domain + DNA binding domain - SIV | **[[1c6v]] – IN catalytic domain + DNA binding domain - SIV | ||
*Rous sarcoma virus integrase | |||
[[1c0m]], [[1c1a]] – IN fragment (mutant) – RSV<br /> | **[[1c0m]], [[1c1a]] – IN fragment (mutant) – RSV<br /> | ||
[[1vsk]], [[1vsl]], [[3o4q]] - IN catalytic core domain (mutant)<br /> | **[[1vsk]], [[1vsl]], [[3o4q]] - IN catalytic core domain (mutant)<br /> | ||
[[1vsm]], [[1vsh]], [[1vsi]], [[1vsj]], [[1vsd]], [[1vse]], [[1vsf]], [[3o4n]] - IN catalytic core domain<br /> | **[[1vsm]], [[1vsh]], [[1vsi]], [[1vsj]], [[1vsd]], [[1vse]], [[1vsf]], [[3o4n]] - IN catalytic core domain<br /> | ||
[[1a5v]], [[1a5w]], [[1a5x]] - IN catalytic core domain + inhibitor | **[[1a5v]], [[1a5w]], [[1a5x]] - IN catalytic core domain + inhibitor | ||
*Avian sarcoma virus integrase | |||
[[1cxq]], [[1cxu]], [[1cz9]], [[1czb]], [[1asu]], [[1asv]], [[1asw]] - IN catalytic core domain (mutant) – ASV | **[[1cxq]], [[1cxu]], [[1cz9]], [[1czb]], [[1asu]], [[1asv]], [[1asw]] - IN catalytic core domain (mutant) – ASV | ||
Bacterial IN | Bacterial IN | ||
*Various integrases | |||
**[[3nkh]] – IN fragment – ''Staphylococcus aureus'' MRSA<br /> | |||
**[[1b69]], [[1tn9]] - EfIN N-terminal DBD + DNA – ''Enterococcus faecalis'' – NMR<br /> | |||
**[[1bb8]], [[2bb8]] - EfIN N-terminal DBD – NMR | |||
}} | |||