Retroviral Integrase: Difference between revisions

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<StructureSection load=1k6y size='450' side='right' scene='' caption=''>
<StructureSection load=1k6y size='450' side='right' scene='' caption='N-terminal and core domain of HIV-1 integrase (PDB code [[1k6y]])'>
[[Image:3l2q.png|left|200px|thumb|Crystal Structure of Integrase [[3l2q]]]]
[[Image:3l2q.png|left|200px|thumb|Crystal Structure of Integrase [[3l2q]]]]


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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|


===Human spumaretrovirus integrase===
*Human spumaretrovirus integrase


[[3os0]], [[3os1]], [[3os2]], [[3oy9]], [[3l2q]], [[3l2r]] – IN + DNA – human spumaretrovirus<br />
**[[3os0]], [[3os1]], [[3os2]], [[3oy9]], [[3l2q]], [[3l2r]] – IN + DNA – human spumaretrovirus<br />
[[3oyb]], [[3oyc]], [[3oyd]], [[3oye]], [[3oyf]], [[3oyg]], [[3oyh]], [[3oyi]], [[3oyj]], [[3oyk]], [[3oyl]], [[3oym]], [[3oyn]], [[3oya]], [[3l2u]], [[3l2v]], [[3l2w]] – IN + DNA + inhibitor<br />
**[[3oyb]], [[3oyc]], [[3oyd]], [[3oye]], [[3oyf]], [[3oyg]], [[3oyh]], [[3oyi]], [[3oyj]], [[3oyk]], [[3oyl]], [[3oym]], [[3oyn]], [[3oya]], [[3l2u]], [[3l2v]], [[3l2w]] – IN + DNA + inhibitor<br />
[[2x6n]], [[2x6s]], [[2x74]], [[2x78]], [[3dlr]] - IN catalytic core domain
**[[2x6n]], [[2x6s]], [[2x74]], [[2x78]], [[3dlr]] - IN catalytic core domain


===Bovine immunodeficiency virus integrase===
*Bovine immunodeficiency virus integrase


[[3kkr]], [[3kks]] – IN catalytic core domain – BIV
**[[3kkr]], [[3kks]] – IN catalytic core domain – BIV


===Human immunodeficiency virus 1 integrase===
*Human immunodeficiency virus 1 integrase


[[3lpt]], [[3lpu]], [[3l3u]], [[1exq]], [[1b92]], [[1b9d]], [[1b9f]], [[1bi4]], [[1bhl]], [[1bl3]], [[1bis]], [[1biu]], [[1biz]], [[2itg]], [[3zcm]] - IN catalytic core domain (mutant) – HIV-1<br />
**[[3lpt]], [[3lpu]], [[3l3u]], [[1exq]], [[1b92]], [[1b9d]], [[1b9f]], [[1bi4]], [[1bhl]], [[1bl3]], [[1bis]], [[1biu]], [[1biz]], [[2itg]], [[3zcm]] - IN catalytic core domain (mutant) – HIV-1<br />
[[3l3v ]]- IN catalytic core domain (mutant) + sucrose<br />
**[[3l3v ]]- IN catalytic core domain (mutant) + sucrose<br />
[[1hyv]], [[1hyz]], [[1qs4]] - IN N-terminal + inhibitor<br />
**[[1hyv]], [[1hyz]], [[1qs4]] - IN N-terminal + inhibitor<br />
[[1k6y]] - IN N-terminal + catalytic core domain<br />
**[[1k6y]] - IN N-terminal + catalytic core domain<br />
[[1itg]] - IN catalytic core domain<br />
**[[1itg]] - IN catalytic core domain<br />
[[1wje]], [[1wjf]] - IN N-terminal zinc-binding domain (mutant) – NMR<br />
**[[1wje]], [[1wjf]] - IN N-terminal zinc-binding domain (mutant) – NMR<br />
[[1wja]], [[1wjb]], [[1wjc]], [[1wjd]] - IN N-terminal zinc-binding domain<br />
**[[1wja]], [[1wjb]], [[1wjc]], [[1wjd]] - IN N-terminal zinc-binding domain<br />
[[1ex4]] - IN C-terminal DBD + catalytic core domain (mutant)<br />
**[[1ex4]] - IN C-terminal DBD + catalytic core domain (mutant)<br />
[[1ihv]], [[1ihw]] – IN DBD - NMR<br />
**[[1ihv]], [[1ihw]] – IN DBD - NMR<br />
[[1qmc]] – IN DBD - NMR<br />
**[[1qmc]] – IN DBD - NMR<br />
[[2b4j]], [[3av9]], [[3ava]], [[3avb]], [[3avc]], [[3avf]], [[3avg]], [[3avh]], [[3avi]], [[3avj]], [[3avk]], [[3avl]], [[3avm]], [[3avn]] - IN (mutant) + lens epithelium-derived growth factor <br />  
**[[2b4j]], [[3av9]], [[3ava]], [[3avb]], [[3avc]], [[3avf]], [[3avg]], [[3avh]], [[3avi]], [[3avj]], [[3avk]], [[3avl]], [[3avm]], [[3avn]] - IN (mutant) + lens epithelium-derived growth factor <br />  
[[3nf6]], [[3nf7]], [[3nf8]], [[3nf9]], [[3nfa]], [[4e1m]], [[4e1n]], [[4cj4]], [[4jlh]] - IN core domain (mutant) + inhibitor<br />  
**[[3nf6]], [[3nf7]], [[3nf8]], [[3nf9]], [[3nfa]], [[4e1m]], [[4e1n]], [[4cj4]], [[4jlh]] - IN core domain (mutant) + inhibitor<br />  


===Human immunodeficiency virus 2 integrase===
*Human immunodeficiency virus 2 integrase


[[3f9k]] - IN N-terminal + catalytic core domain + LEDGF IBD – HIV-2<br />
**[[3f9k]] - IN N-terminal + catalytic core domain + LEDGF IBD – HIV-2<br />
[[1e0e]] - IN N-terminal – NMR
**[[1e0e]] - IN N-terminal – NMR


===Moloney murine leukemia virus integrase===
*Moloney murine leukemia virus integrase


[[3nnq]] – IN N-terminal – MOMLV
**[[3nnq]] – IN N-terminal – MOMLV


===Maedi Visna virus integrase===
*Maedi Visna virus integrase


[[3hpg]], [[3hph]] – IN N-terminal + catalytic core domain + LEDGF IBD – MVV
**[[3hpg]], [[3hph]] – IN N-terminal + catalytic core domain + LEDGF IBD – MVV


===Simian immunodeficiency virus integrase===
*Simian immunodeficiency virus integrase


[[1c6v]] – IN catalytic domain + DNA binding domain - SIV  
**[[1c6v]] – IN catalytic domain + DNA binding domain - SIV  


===Rous sarcoma virus integrase===
*Rous sarcoma virus integrase


[[1c0m]], [[1c1a]] – IN fragment (mutant) – RSV<br />
**[[1c0m]], [[1c1a]] – IN fragment (mutant) – RSV<br />
[[1vsk]], [[1vsl]], [[3o4q]] - IN catalytic core domain (mutant)<br />
**[[1vsk]], [[1vsl]], [[3o4q]] - IN catalytic core domain (mutant)<br />
[[1vsm]], [[1vsh]], [[1vsi]], [[1vsj]], [[1vsd]], [[1vse]], [[1vsf]], [[3o4n]] - IN catalytic core domain<br />
**[[1vsm]], [[1vsh]], [[1vsi]], [[1vsj]], [[1vsd]], [[1vse]], [[1vsf]], [[3o4n]] - IN catalytic core domain<br />
[[1a5v]], [[1a5w]], [[1a5x]] - IN catalytic core domain + inhibitor  
**[[1a5v]], [[1a5w]], [[1a5x]] - IN catalytic core domain + inhibitor  


===Avian sarcoma virus integrase===
*Avian sarcoma virus integrase


[[1cxq]], [[1cxu]], [[1cz9]], [[1czb]], [[1asu]], [[1asv]], [[1asw]] - IN catalytic core domain (mutant) – ASV
**[[1cxq]], [[1cxu]], [[1cz9]], [[1czb]], [[1asu]], [[1asv]], [[1asw]] - IN catalytic core domain (mutant) – ASV
Bacterial IN
Bacterial IN


[[3nkh]] – IN fragment – Staphylococcus aureus MRSA<br />
*Various integrases
[[1b69]], [[1tn9]] - EfIN N-terminal DBD + DNA – Enterococcus faecalis – NMR<br />
[[1bb8]], [[2bb8]] - EfIN N-terminal DBD – NMR


**[[3nkh]] – IN fragment – ''Staphylococcus aureus'' MRSA<br />
**[[1b69]], [[1tn9]] - EfIN N-terminal DBD + DNA – ''Enterococcus faecalis'' – NMR<br />
**[[1bb8]], [[2bb8]] - EfIN N-terminal DBD – NMR
}}