ABC transporter: Difference between revisions

Revision as of 13:56, 11 November 2014

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Se-Met B12 Bacterial ABC Transporter complex with cyclo-tetrametavanadate, 1l7v. Permease protein in green and grey, ATP-binding protein in yellow and pink.

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ATP Binding Cassette (ABC) Transporters are ATP-dependent membrane proteins critical for most aspects of cell physiology, including the uptake of nutrients (importers) and elimination of waste products and energy generation (exporters) which are predominantly expressed in excretory organs, such as the liver, intestine, blood-brain barrier, blood-testes barrier, placenta, and kidney^[1]^[2]. There are many ABC Transporters in organisms, for instance, there are 28 in Saccharomyces,58 in Caenorhabditis, 51 in Drosophila,129 in Arabadopsis,and the 69 ABC transporters in E. coli account for almost 5% of its genomic coding capacity^[3]. ABC transporter protein translocates substrates across membranes. It contains a Solute Binding Domain (SBD). CFTR (Cystic Fibrosis Transmembrane Regulator) translocates chloride and thiocyanate. It contains a nucleotide binding domain (NBD). Mutations in CFTR lead to Cystic Fibrosis. In humans the ABC transporters are classified into subfamilies, i.e. ABCB6 is ABC subfamily B member 6. The images at the left and at the right correspond to one representative ABC transporter, i.e. the crystal structure of B12 Bacterial ABC Transporter (1l7v).

Function

ABC Transporters has two main functionality acting either as exporters or importers. ABC Exporters release bound drugs to the extracellular environment, while ABC Importers accept substrate molecules from their relevant substrate-binding proteins^[4]. For instance the Vitamin B12 transporter BtuCD (PDB 1l7v) is a binding protein-dependent ABC transporter system that uses the power of ATP hydrolysis to pump vitamin B12 into the cytoplasm of E. coli^[5].

ABC Exporters Use ATP to drive import and export functions providing multidrug resistance. In eukaryoles, for instance, ABC Transporters are problematic because they export therapeutic drugs such as those used in chemotherapy regimens, which must be changed frequently to avoid the rejection of the drugs^[4].

To achieve export, ABC transporters require a minimum of four domains. Two transmembrane domains (TMDs) form the ligand binding sites and provide specificity, and two NBDs bind and hydrolyze ATP to drive the trans-location of the bound ligand. The NBDs, but not the TMDs, are homologous throughout the family and have several characteristic motifs including the Walker A and B motifs common to many nucleotide binding proteins and others like the ABC signature, stacking aromatic D, H, and Q loops, which are unique to the family^[2].

↑ Cite error: Invalid <ref> tag; no text was provided for refs named Kidney
↑ ^2.0 ^2.1 Cite error: Invalid <ref> tag; no text was provided for refs named FourDomainsABCT
↑ Cite error: Invalid <ref> tag; no text was provided for refs named EColi
↑ ^4.0 ^4.1 Cite error: Invalid <ref> tag; no text was provided for refs named biochembook
↑ Cite error: Invalid <ref> tag; no text was provided for refs named BtuCD-Ecoli

3D Structures of ABC transporter

Updated on 11-November-2014

ABC amino acids transporters
- Arginine ABC transporter
  - Transporters - CpABC arginine transporter, soluble domain (mutant) – Chlamydia pneumoniae
  - 1l7v - CpABC arginine transporter, soluble domain
  - 1l7v - CbABC arginine transporter + arginine – Coxiella burnetii
  - 2q2a - GsABC amino acids transporter (mutant)+arginine - Geobacillus stearothermophilus
  - 3del - ABC arginine transporter – Chlamydia trachomatis
- Branched amino acid ABC transporter
  - 3lkb - TtABC branched amino acids transporter (mutant)+valine – Thermus thermophilus
  - 3h5l - SpABC branched-chain amino acids transporter
  - 1g9x, 1g6h, 1gaj - ABC branched-chain amino acids transporter – Methanocaldococcus jannaschii
  - 3td9 - TmABC branched-chain amino acids transporter + phenylalanine - Thermotoga maritima
  - 3i09, 3n0w - ABC branched amino acids transporter – Burkholderia mallei
  - 3ip7 – AtABC valine transporter
  - 3ipc – AtABC leucine transporter
- Lysine ABC transporter
  - 3k4u - ABC transporter + lysine – Wolinella succinogenes
  - 3i6v - SpABC amino acids transporter + lysine – Silicibacter pomeroyi
  - 2pvu - GsABC amino acids transporter (mutant)+lysine
- Histidine ABC transporter
  - 2q2c - GsABC amino acids transporter (mutant)+histidine
- Methionine ABC transporter
  - 2qsw - EfABC methionine transporter C-terminal – Enterococcus faecalis
  - 3ced - SaABC methionine transporter NIL domain - Staphylococcus aureus
  - 3tqw - CbABC methionine transporter + methionine
  - 3dhw - EcABC methionine transporter
  - 3dhx- EcABC methionine transporter C2 domain
  - 2qrr - ABC methionine transporter soluble domain - Vibrio parahaemolyticus
- Alanine ABC transporter
  - 3ip5, 3ipa – AtABC alanine transporter – Agrobacterium tumefaciens
- Proline ABC transporter
  - 3ip6 – AtABC proline transporter
  - 3tmg - BbABC proline transporter – Borrelia burgdorferi
- Polar amino acid ABC transporter
  - 3hv1 - ABC polar amino acids transporter SBD – Streptococcus thermophilus
- Unspecified amino acid ABC transporter
  - 3c41 - GsABC amino acids transporter +AMP-PNP
  - 3c4j - GsABC amino acids transporter +ATPgS
  - 2olj - EcABC amino acid transporter+ADP/Mg – Escherichia coli
  - 2olk - EcABC amino acid transporter+ADP-beta-S
  - 2ouk - EcABC amino acid transporter+sulfate
  - 3o6p - EfABC amino acids transporter
  - 3ip9 – AtABC amino acid transporter+GABA
- Cationic amino acid ABC transporter
  - 2m8c - EcABC amino acids transporter
- Oligopeptide ABC transporter
  - 3i5o, 1vr5 - TmABC oligopeptides transporter
  - 4gl8 - BbABC oligopeptide transporter + peptide
  - 4ikv, 4ikw - GkABC oligopeptides transporter – Geobacillus kaustophilus
  - 4ikx, 4iky - GkABC oligopeptides transporter (mutant)
  - 4ikz - GkABC oligopeptides transporter (mutant) + alafosfalin
  - 2d5w - TtABC oligopeptide transporter + peptide
ABC sugar transporters
- 2vk2 - EcABC galactofuranose transporter +galactofuranose
- 2xz3 – EcABC maltose trasnsporter + maltose
- 3puy, 3puz - EcABC maltose trasnsporter MalK, MalF, MalG, MBP + maltose + AMPPNP
- 3rlf - EcABC maltose trasnsporter MalK, MalF, MalG, MBP + maltose + AMPPNP
- 4khz - EcABC maltose trasnsporter MalK, MalF, MalG, MBP
- 4jbw - EcABC maltose trasnsporter MalK, MalF, MalG + EIIAGLC
- 3pv0 - EcABC maltose trasnsporter MalK, MalF, MalG, MBP + maltose
- 2r6g, 3puv, 3puw, 3pux, 4ki0 - EcABC maltose trasnsporter MalK, MalF, MalG, MBP + maltose + nucleotide
- 3fh6 - EcABC maltose trasnsporter MalK, MalF, MalG
- 3ob4 - EcABC maltose transsporter AraH2 (mutant) + maltotriose
- 2w7y - SpABC sugar transporter+A-trisaccaride – Streptococcus pneumoniae
- 2i58 - SpABC sugar transporter+raffinose
- 2hq0, 2heu, 2hfb - SpABC sugar transporter
- 3g1w - BhABC sugar transporter – Bacillus halodurans
- 2z8d - BlABC lacto-N-biose transporter SBD+lacto-N-biose – Bifidobacterium longum
- 2z8e - BlABC lacto-N-biose transporter SBD+galacto-N-biose
- 2z8f - BlABC lacto-N-biose transporter SBD+lacto-N-tetraose
- 3c6q - TmABC sugar transporter (mutant)+beta-xylopyranose
- 2yyz, 2qvc, 2h3h, 2hpg, 2ghb - TmABC sugar transporter
- 2fn9 - TmABC sugar transporter (mutant)
- 2o7i - TmABC sugar transporter+cellobiose
- 2gha, 2fnc - TmABC sugar transporter+maltotriose
- 2fn8 - TmABC sugar transporter+ribose
- 1vci, 1v43 - PhABC sugar transporter – Pyrococcus horikoshii
- 1oxx, 1oxs, 1oxt, 1oxu, 1oxv - ABC glucose transporter (mutant) – Sulfolobus solfataricus
- 3l49 - ABC ribose transporter – Rhodobacter sphaeroides
ABC metal transporters
- ABC metal transporters
  - 3hh8 - ABC metal transporter – Streptococcus pyogenes
- ABC cobalt transporters
  - 3gfo - ABC cobalt transporter – Clostridium perfringens
- ABC nickel transporters
  - 3t66 - BhABC nickel transporter (mutant)
- ABC tungsten transporters
  - 3lr1 - ABC tungstate transporter – Geobacter sulfurreducens
  - 2onk - AfABC molybdate/tungstate transporter+Mo/W binding protein – Archaeoglobus fulgidus
  - 2onr - AfABC molybdate/tungstate transporter+Mo
  - 2ons - AfABC molybdate/tungstate transporter+W
- ABC iron transporters
  - 3lhs, 3li2 - SaABC OpuAC ferrichrome transporter fragment+Staphyloferrin A
  - 3mwf, 3mwg - SaABC siderophore transporter +Staphyloferrin B
  - 3g9q, 3hxp - BsABC ferrichrome transporter
  - 3be5, 3be6 - EcABC iron transporter
  - 2etv - TmABC iron transporter
- ABC molybden transporters
  - 3d31 - MaABC sulfate/molybdate transporter – Methanosarcina acetivorans
  - 3cfx - MaABC sulfate/molybdate transporter + WO4
  - 3cfz - MjABC sulfate/molybdate transporter + WO4
  - 3cg1 - ABC sulfate/molybdate transporter + WO4 – Pyrococcus furiosus
  - 3cg3 - PhABC sulfate/molybdate transporter + WO4
- ABC zinc transporters
  - 2ogw - EcABC zinc transporter
  - 2xh8 - SeABC zinc transporter (mutant) – Salmonella enterica
  - 2xqv - SeABC zinc transporter + Zn
  - 2xy4 - SeABC zinc transporter
  - 2ov3, 2ov1, 1pq4 - SsABC zinc transporter – Synechocystis
ABC multidrug transporters
- 2onj - SaABC multidrug transporter+AMP-PNP
- 2hyd - SaABC multidrug transporter
- 1mv5 - LlABC multidrug transporter ATP binding domain – Lactococcus lactis
ABC choline transporters
- 3hcq - SmABC choline transporter (mutant) – Sinorhizobium meliloti
- 2rin - SmABC choline transporter (mutant)+acetylcholine
- 2reg - SmABC choline transporter (mutant)+choline
- 2rej, 2rf1 - SmABC choline transporter (mutant)
- 3o66 – SaABC choline transporter
ABC alpha-hemolysin transporters
- 2pmk - EcABC alpha-hemolysin transporter+TNP-ADP
- 2ff7 - EcABC alpha-hemolysin transporter+ADP
- 2ffa, 2ffb - EcABC alpha-hemolysin transporter (mutant)+ADP
- 2fgj, 2fgk, 2xef - EcABC alpha-hemolysin transporter (mutant)+ATP
- 3b5j - EcABC alpha-hemolysin transporter (mutant)+TNP-ADP
ABC various compounds transporters
- 2v84 - ABC spermidine/putrescine transporter – Treponema pallidum
- 2qi9 - EcABC vitamin B12 transporter+BtuD+BtuF
- 1l7v - EcABC vitamin B12 transporter+BtuD
- 3p7i, 3qk6, 3quj, 3s4u – EcABC alkylphosphonate transporter PHND + aminoethyl phosphonic acid
- 1twy - ABC phosphate transporter – Vibrio cholerae
- 3l6g, 3l6h – LlABC OpuAC betaine transporter SBD
- 2zzv - TtABC solute transporter+lactate+Ca
- 2zzw - TtABC solute transporter+lactate+Zn
- 2zzx - TtABC solute transporter+lactate
- 3gfv - BsABC petrobactin transporter – Bacillus subtilis
- 3bk7 – ABC ATP-binding – Pyrococcus abyssi
- 3ppn - BsABC multiple solute transporter
- 3ppo, 3ppp, 3ppq, 3ppr - BsABC multiple solute transporter + solute
- 3hn0 – ABC NO3 transporter – Parabacteroides distasonis
- 3rlb - LlABC vitamin B1 transporter + thiamin
- 4dve - LlABC biotin transporter + biotin
hABC transporters subfamilies
- 3nh6 – hABCB6 NBD
- 3nhb – hABCB6 NBD+ADP
- 3nh9 – hABCB6 NBD+ATP
- 3nha – hABCB6 NBD+ATP+Mg
ABC unspecified transporters
- 3lvu - SpABC transporter SBD
- 2ihy - SaABC transporter ATPase subunit
- 3eaf - ABC transporter SBD – Aeropyrum pernix
- 3c9h - AtABC transporter – Agrobacterium tumefaciens
- 1vpl, 1ji0 - TmABC transporter
- 2pcj, 2pcl - ABC transporter – Aquifex aeolicus
- 3rpw - ABC transporter – Rhodopseudomonas palustris
- 2yl4 - hABC transporter 10
- 4g68 – ABC transporter - Caldanaerobius
Cystic fibrosis transmembrane conductance regulator (CFTR)
- 3gd7 – hCFTR/malK+N6-phenylethyl-ATP
- 2pze, 2pzf, 2pzg – hCFTR NBD1
- 2bbo, 2bbs, 2bbt - hCFTR NBD1 (mutant)
- 1xmi, 2xmj, 1xmj - hCFTR NBD1 (mutant)+ATP
- 1xf9, 2xfa, 1xfa - mCFTR NBD1 (mutant) - mouse
- 1q3h - mCFTR NBD1+AMPPNP
- 1r0w - mCFTR NBD1
- 1r0x, 1r0z, 1r10 - mCFTR NBD1+ATP
- 1r0y - mCFTR NBD1+ADP
- 1ckw, 1ckx, 1cky, 1ckz – CFTR F508 region - NMR

References

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Zina Saadi, Joel L. Sussman, Michal Harel

[Kidney-1] Cite error: Invalid <ref> tag; no text was provided for refs named Kidney

[FourDomainsABCT-2] 2.0 ^2.1 Cite error: Invalid <ref> tag; no text was provided for refs named FourDomainsABCT

[EColi-3] Cite error: Invalid <ref> tag; no text was provided for refs named EColi

[biochembook-4] 4.0 ^4.1 Cite error: Invalid <ref> tag; no text was provided for refs named biochembook

[BtuCD-Ecoli-5] Cite error: Invalid <ref> tag; no text was provided for refs named BtuCD-Ecoli

[1]

[2]

[3]

[4]

[5]

ABC transporter: Difference between revisions

Revision as of 13:56, 11 November 2014

Function

3D Structures of ABC transporter

References

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@@ Line 38: / Line 38: @@
 ***[[3ipc]] – AtABC leucine transporter<br />
-''Lysine ABC transporter''
+**Lysine ABC transporter
-[[3k4u]] - ABC transporter + lysine – ''Wolinella succinogenes''<br />
+***[[3k4u]] - ABC transporter + lysine – ''Wolinella succinogenes''<br />
-[[3i6v]] - SpABC amino acids transporter + lysine – ''Silicibacter pomeroyi''<br />
+***[[3i6v]] - SpABC amino acids transporter + lysine – ''Silicibacter pomeroyi''<br />
-[[2pvu]] - GsABC amino acids transporter (mutant)+lysine<br />
+***[[2pvu]] - GsABC amino acids transporter (mutant)+lysine<br />
-''Histidine ABC transporter''
+**Histidine ABC transporter
-[[2q2c]] - GsABC amino acids transporter (mutant)+histidine<br />
+***[[2q2c]] - GsABC amino acids transporter (mutant)+histidine<br />
-''Methionine ABC transporter''
+**Methionine ABC transporter
-[[2qsw]] - EfABC methionine transporter C-terminal – ''Enterococcus faecalis''<br />
+***[[2qsw]] - EfABC methionine transporter C-terminal – ''Enterococcus faecalis''<br />
-[[3ced]] - SaABC methionine transporter NIL domain - ''Staphylococcus aureus''<br />
+***[[3ced]] - SaABC methionine transporter NIL domain - ''Staphylococcus aureus''<br />
-[[3tqw]] - CbABC methionine transporter + methionine <br />
+***[[3tqw]] - CbABC methionine transporter + methionine <br />
-[[3dhw]] - EcABC methionine transporter<br />
+***[[3dhw]] - EcABC methionine transporter<br />
-[[3dhx ]]- EcABC methionine transporter C2 domain<br />
+***[[3dhx]]- EcABC methionine transporter C2 domain<br />
-[[2qrr]] - ABC methionine transporter soluble domain - ''Vibrio parahaemolyticus'' <br />
+***[[2qrr]] - ABC methionine transporter soluble domain - ''Vibrio parahaemolyticus'' <br />
-''Alanine ABC transporter''
+**Alanine ABC transporter
-[[3ip5]], [[3ipa]] – AtABC alanine transporter  – ''Agrobacterium tumefaciens''<br />
+***[[3ip5]], [[3ipa]] – AtABC alanine transporter  – ''Agrobacterium tumefaciens''<br />
-''Proline ABC transporter''
+**Proline ABC transporter
-[[3ip6]] – AtABC proline transporter<br />
+***[[3ip6]] – AtABC proline transporter<br />
-[[3tmg]] - BbABC proline transporter – ''Borrelia burgdorferi''<br / >
+***[[3tmg]] - BbABC proline transporter – ''Borrelia burgdorferi''<br / >
-''Polar amino acid ABC transporter''
+**Polar amino acid ABC transporter
-[[3hv1]] - ABC polar amino acids transporter SBD – ''Streptococcus thermophilus''<br />
+***[[3hv1]] - ABC polar amino acids transporter SBD – ''Streptococcus thermophilus''<br />
-''Unspecified amino acid ABC transporter''
+**Unspecified amino acid ABC transporter
-[[3c41]] - GsABC amino acids transporter +AMP-PNP <br />
+***[[3c41]] - GsABC amino acids transporter +AMP-PNP <br />
-[[3c4j]] - GsABC amino acids transporter +ATPgS<br />
+***[[3c4j]] - GsABC amino acids transporter +ATPgS<br />
-[[2olj]] - EcABC amino acid transporter+ADP/Mg – ''Escherichia coli''<br />
+***[[2olj]] - EcABC amino acid transporter+ADP/Mg – ''Escherichia coli''<br />
-[[2olk]] - EcABC amino acid transporter+ADP-beta-S<br />
+***[[2olk]] - EcABC amino acid transporter+ADP-beta-S<br />
-[[2ouk]] - EcABC amino acid transporter+sulfate<br />
+***[[2ouk]] - EcABC amino acid transporter+sulfate<br />
-[[3o6p]] - EfABC amino acids transporter<br />
+***[[3o6p]] - EfABC amino acids transporter<br />
-[[3ip9]] – AtABC amino acid transporter+GABA<br />
+***[[3ip9]] – AtABC amino acid transporter+GABA<br />
-''Cationic amino acid ABC transporter''
+**Cationic amino acid ABC transporter
-[[2m8c]] - EcABC amino acids transporter<br />
+***[[2m8c]] - EcABC amino acids transporter<br />
-''Oligopeptide ABC transporter''
+**Oligopeptide ABC transporter
-[[3i5o]], [[1vr5]] - TmABC oligopeptides transporter <br />
+***[[3i5o]], [[1vr5]] - TmABC oligopeptides transporter <br />
-[[4gl8]] - BbABC oligopeptide transporter + peptide<br />
+***[[4gl8]] - BbABC oligopeptide transporter + peptide<br />
-[[4ikv]], [[4ikw]] - GkABC oligopeptides transporter – ''Geobacillus kaustophilus''<br />
+***[[4ikv]], [[4ikw]] - GkABC oligopeptides transporter – ''Geobacillus kaustophilus''<br />
-[[4ikx]], [[4iky]] - GkABC oligopeptides transporter (mutant)<br />
+***[[4ikx]], [[4iky]] - GkABC oligopeptides transporter (mutant)<br />
-[[4iky]] - GkABC oligopeptides transporter (mutant) + alafosfalin<br />
+***[[4ikz]] - GkABC oligopeptides transporter (mutant) + alafosfalin<br />
-[[2d5w]] - TtABC oligopeptide transporter + peptide<br />
+***[[2d5w]] - TtABC oligopeptide transporter + peptide<br />
-=== ABC sugar transporters ===
+* ABC sugar transporters
-[[2vk2]] - EcABC galactofuranose transporter +galactofuranose<br />
+**[[2vk2]] - EcABC galactofuranose transporter +galactofuranose<br />
-[[2xz3]] – EcABC maltose trasnsporter + maltose<br />
+**[[2xz3]] – EcABC maltose trasnsporter + maltose<br />
-[[3puy]], [[3puz]] - EcABC maltose trasnsporter MalK, MalF, MalG, MBP + maltose + AMPPNP<br />
+**[[3puy]], [[3puz]] - EcABC maltose trasnsporter MalK, MalF, MalG, MBP + maltose + AMPPNP<br />
-[[3rlf]] - EcABC maltose trasnsporter MalK, MalF, MalG, MBP + maltose + AMPPNP<br />
+**[[3rlf]] - EcABC maltose trasnsporter MalK, MalF, MalG, MBP + maltose + AMPPNP<br />
-[[4khz]] - EcABC maltose trasnsporter MalK, MalF, MalG, MBP <br />
+**[[4khz]] - EcABC maltose trasnsporter MalK, MalF, MalG, MBP <br />
-[[4jbw]] - EcABC maltose trasnsporter MalK, MalF, MalG + EIIAGLC<br />
+**[[4jbw]] - EcABC maltose trasnsporter MalK, MalF, MalG + EIIAGLC<br />
-[[3pv0]] - EcABC maltose trasnsporter MalK, MalF, MalG, MBP + maltose <br />
+**[[3pv0]] - EcABC maltose trasnsporter MalK, MalF, MalG, MBP + maltose <br />
-[[2r6g]], [[3puv]], [[3puw]], [[3pux]], [[4ki0]] - EcABC maltose trasnsporter MalK, MalF, MalG, MBP + maltose + nucleotide<br />
+**[[2r6g]], [[3puv]], [[3puw]], [[3pux]], [[4ki0]] - EcABC maltose trasnsporter MalK, MalF, MalG, MBP + maltose + nucleotide<br />
-[[3fh6]] - EcABC maltose trasnsporter MalK, MalF, MalG <br />
+**[[3fh6]] - EcABC maltose trasnsporter MalK, MalF, MalG <br />
-[[3ob4]] - EcABC maltose transsporter AraH2 (mutant) + maltotriose<br />
+**[[3ob4]] - EcABC maltose transsporter AraH2 (mutant) + maltotriose<br />
-[[2w7y]] - SpABC sugar transporter+A-trisaccaride – ''Streptococcus pneumoniae''<br />
+**[[2w7y]] - SpABC sugar transporter+A-trisaccaride – ''Streptococcus pneumoniae''<br />
-[[2i58]] - SpABC sugar transporter+raffinose<br />
+**[[2i58]] - SpABC sugar transporter+raffinose<br />
-[[2hq0]], [[2heu]], [[2hfb]] - SpABC sugar transporter<br />
+**[[2hq0]], [[2heu]], [[2hfb]] - SpABC sugar transporter<br />
-[[3g1w]] - BhABC sugar transporter – ''Bacillus halodurans''<br />
+**[[3g1w]] - BhABC sugar transporter – ''Bacillus halodurans''<br />
-[[2z8d]] - BlABC lacto-N-biose transporter SBD+lacto-N-biose – ''Bifidobacterium longum''<br />
+**[[2z8d]] - BlABC lacto-N-biose transporter SBD+lacto-N-biose – ''Bifidobacterium longum''<br />
-[[2z8e]] - BlABC lacto-N-biose transporter SBD+galacto-N-biose<br />
+**[[2z8e]] - BlABC lacto-N-biose transporter SBD+galacto-N-biose<br />
-[[2z8f]] - BlABC lacto-N-biose transporter SBD+lacto-N-tetraose<br />
+**[[2z8f]] - BlABC lacto-N-biose transporter SBD+lacto-N-tetraose<br />
-[[3c6q]] - TmABC sugar transporter (mutant)+beta-xylopyranose<br />
+**[[3c6q]] - TmABC sugar transporter (mutant)+beta-xylopyranose<br />
-[[2yyz]], [[2qvc]], [[2h3h]], [[2hpg]], [[2ghb]] - TmABC sugar transporter<br />
+**[[2yyz]], [[2qvc]], [[2h3h]], [[2hpg]], [[2ghb]] - TmABC sugar transporter<br />
-[[2fn9]] - TmABC sugar transporter (mutant)<br />
+**[[2fn9]] - TmABC sugar transporter (mutant)<br />
-[[2o7i]] - TmABC sugar transporter+cellobiose<br />
+**[[2o7i]] - TmABC sugar transporter+cellobiose<br />
-[[2gha]] , [[2fnc]] - TmABC sugar transporter+maltotriose<br />
+**[[2gha]], [[2fnc]] - TmABC sugar transporter+maltotriose<br />
-[[2fn8]] - TmABC sugar transporter+ribose<br />
+**[[2fn8]] - TmABC sugar transporter+ribose<br />
-[[1vci]], [[1v43]] - PhABC sugar transporter – ''Pyrococcus horikoshii''
+**[[1vci]], [[1v43]] - PhABC sugar transporter – ''Pyrococcus horikoshii''<br />
-<br />
+**[[1oxx]], [[1oxs]], [[1oxt]], [[1oxu]], [[1oxv]] - ABC glucose transporter (mutant) – ''Sulfolobus solfataricus''<br />
-[[1oxx]], [[1oxs]], [[1oxt]], [[1oxu]], [[1oxv]] - ABC glucose transporter (mutant) – ''Sulfolobus solfataricus''<br />
+**[[3l49]] - ABC ribose transporter – ''Rhodobacter sphaeroides''<br />
-[[3l49]] - ABC ribose transporter – ''Rhodobacter sphaeroides''<br />
-=== ABC metal transporters ===
+* ABC metal transporters
-[[3hh8]] - ABC metal transporter – ''Streptococcus pyogenes''<br />
+** ABC metal transporters
-[[3gfo]] - ABC cobalt transporter – ''Clostridium perfringens''<br />
-[[3t66]] - BhABC nickel transporter (mutant)<br />
-[[3lr1]] - ABC tungstate transporter – ''Geobacter sulfurreducens''<br />
-[[3lhs]], [[3li2]] - SaABC OpuAC ferrichrome transporter fragment+Staphyloferrin A <br />
-[[3mwf]], [[3mwg]] - SaABC siderophore transporter +Staphyloferrin B<br />
-[[3g9q]], [[3hxp]] - BsABC ferrichrome transporter<br />
-[[3be5]], [[3be6]] - EcABC iron transporter <br />
-[[3d31]] - MaABC sulfate/molybdate transporter – ''Methanosarcina acetivorans''<br />
-[[3cfx]] - MaABC sulfate/molybdate transporter + WO4<br />
-[[3cfz]] - MjABC sulfate/molybdate transporter + WO4<br />
-[[3cg1]] - ABC sulfate/molybdate transporter + WO4 – ''Pyrococcus furiosus''<br />
-[[3cg3]] - PhABC sulfate/molybdate transporter + WO4<br />
-[[2etv]] - TmABC iron transporter <br />
-[[2ogw]] - EcABC zinc transporter<br />
-[[2xh8]] - SeABC zinc transporter (mutant) – S''almonella enterica''<br />
-[[2xqv]] - SeABC zinc transporter + Zn<br />
-[[2xy4]] - SeABC zinc transporter<br />
-[[2ov3]], [[2ov1]], [[1pq4]] - SsABC zinc transporter – ''Synechocystis''<br />
-[[2onk]] - AfABC molybdate/tungstate transporter+Mo/W binding protein – ''Archaeoglobus fulgidus''<br />
-[[2onr]] - AfABC molybdate/tungstate transporter+Mo<br />
-[[2ons]] - AfABC molybdate/tungstate transporter+W<br />
-=== ABC multidrug transporters ===
+***[[3hh8]] - ABC metal transporter – ''Streptococcus pyogenes''<br />
-[[2onj]] - SaABC multidrug transporter+AMP-PNP<br />
+** ABC cobalt transporters
-[[2hyd]] - SaABC multidrug transporter<br />
-[[1mv5]] - LlABC multidrug transporter ATP binding domain – ''Lactococcus lactis''
-=== ABC choline transporters ===
+***[[3gfo]] - ABC cobalt transporter – ''Clostridium perfringens''<br />
-[[3hcq]] - SmABC choline transporter (mutant) – ''Sinorhizobium meliloti''<br />
+** ABC nickel transporters
-[[2rin]] - SmABC choline transporter (mutant)+acetylcholine<br />
-[[2reg]] - SmABC choline transporter (mutant)+choline<br />
-[[2rej]], [[2rf1]] - SmABC choline transporter (mutant)<br />
-[[3o66]] – SaABC choline transporter
-=== ABC alpha-hemolysin transporters ===
+***[[3t66]] - BhABC nickel transporter (mutant)<br />
-[[2pmk]] - EcABC alpha-hemolysin transporter+TNP-ADP<br />
+** ABC tungsten transporters
-[[2ff7]] - EcABC alpha-hemolysin transporter+ADP<br />
-[[2ffa]], [[2ffb]] - EcABC alpha-hemolysin transporter (mutant)+ADP<br />
-[[2fgj]], [[2fgk]], [[2xef]] - EcABC alpha-hemolysin transporter (mutant)+ATP<br />
-[[3b5j]] - EcABC alpha-hemolysin transporter (mutant)+TNP-ADP<br />
-=== ABC various compounds transporters ===
+***[[3lr1]] - ABC tungstate transporter – ''Geobacter sulfurreducens''<br />
+***[[2onk]] - AfABC molybdate/tungstate transporter+Mo/W binding protein – ''Archaeoglobus fulgidus''<br />
+***[[2onr]] - AfABC molybdate/tungstate transporter+Mo<br />
+***[[2ons]] - AfABC molybdate/tungstate transporter+W<br />
-[[2v84]] - ABC spermidine/putrescine transporter – ''Treponema pallidum''<br />
+** ABC iron transporters
-[[2qi9]] - EcABC vitamin B12 transporter+BtuD+BtuF<br />
-[[1l7v]] - EcABC vitamin B12 transporter+BtuD<br />
-[[3p7i]], [[3qk6]], [[3quj]], [[3s4u]] – EcABC alkylphosphonate transporter PHND + aminoethyl phosphonic acid<br />
-[[1twy]] - ABC phosphate transporter – ''Vibrio cholerae''<br />
-[[3l6g]], [[3l6h]] – LlABC OpuAC betaine transporter SBD <br />
-[[2zzv]] - TtABC solute transporter+lactate+Ca<br />
-[[2zzw]] - TtABC solute transporter+lactate+Zn<br />
-[[2zzx]] - TtABC solute transporter+lactate<br />
-[[3gfv]] - BsABC petrobactin transporter – ''Bacillus subtilis''<br />
-[[3bk7]] – ABC ATP-binding – ''Pyrococcus abyssi''<br />
-[[3ppn]] - BsABC multiple solute transporter<br />
-[[3ppo]], [[3ppp]], [[3ppq]], [[3ppr]] - BsABC multiple solute transporter + solute<br />
-[[3hn0]] – ABC NO3 transporter – ''Parabacteroides distasonis''<br />
-[[3rlb]] - LlABC vitamin B1 transporter + thiamin<br />
-[[4dve]] - LlABC biotin transporter + biotin
-===hABC transporters subfamilies===
+***[[3lhs]], [[3li2]] - SaABC OpuAC ferrichrome transporter fragment+Staphyloferrin A <br />
+***[[3mwf]], [[3mwg]] - SaABC siderophore transporter +Staphyloferrin B<br />
+***[[3g9q]], [[3hxp]] - BsABC ferrichrome transporter<br />
+***[[3be5]], [[3be6]] - EcABC iron transporter <br />
+***[[2etv]] - TmABC iron transporter <br />
-[[3nh6]] – hABCB6 NBD<br />
+** ABC molybden transporters
-[[3nhb]] – hABCB6 NBD+ADP<br />
-[[3nh9]] – hABCB6 NBD+ATP<br />
-[[3nha]] – hABCB6 NBD+ATP+Mg
-=== ABC unspecified transporters ===
+***[[3d31]] - MaABC sulfate/molybdate transporter – ''Methanosarcina acetivorans''<br />
+***[[3cfx]] - MaABC sulfate/molybdate transporter + WO4<br />
+***[[3cfz]] - MjABC sulfate/molybdate transporter + WO4<br />
+***[[3cg1]] - ABC sulfate/molybdate transporter + WO4 – ''Pyrococcus furiosus''<br />
+***[[3cg3]] - PhABC sulfate/molybdate transporter + WO4<br />
-[[3lvu]] - SpABC transporter SBD <br />
+** ABC zinc transporters
-[[2ihy]] - SaABC transporter ATPase subunit <br />
-[[3eaf]] - ABC transporter SBD – ''Aeropyrum pernix''<br />
-[[3c9h]] - AtABC transporter – ''Agrobacterium tumefaciens''<br />
-[[1vpl]], [[1ji0]] - TmABC transporter  <br />
-[[2pcj]], [[2pcl]] - ABC transporter – ''Aquifex aeolicus''<br />
-[[3rpw]] - ABC transporter – ''Rhodopseudomonas palustris''<br />
-[[2yl4]] - hABC transporter 10<br />
-[[4g68]] – ABC transporter - ''Caldanaerobius''
-=== Cystic fibrosis transmembrane conductance regulator (CFTR) ===
+***[[2ogw]] - EcABC zinc transporter<br />
+***[[2xh8]] - SeABC zinc transporter (mutant) – ''Salmonella enterica''<br />
+***[[2xqv]] - SeABC zinc transporter + Zn<br />
+***[[2xy4]] - SeABC zinc transporter<br />
+***[[2ov3]], [[2ov1]], [[1pq4]] - SsABC zinc transporter – ''Synechocystis''<br />
-[[3gd7]] – hCFTR/malK+N6-phenylethyl-ATP<br />
+* ABC multidrug transporters
-[[2pze]], [[2pzf]], [[2pzg]] – hCFTR NBD1<br />
-[[2bbo]], [[2bbs]], [[2bbt]] - hCFTR NBD1 (mutant)<br />
+**[[2onj]] - SaABC multidrug transporter+AMP-PNP<br />
-[[1xmi]], [[2xmj]], [[1xmj]] - hCFTR NBD1 (mutant)+ATP<br />
+**[[2hyd]] - SaABC multidrug transporter<br />
-[[1xf9]], [[2xfa]], [[1xfa]] - mCFTR NBD1 (mutant) - mouse<br />
+**[[1mv5]] - LlABC multidrug transporter ATP binding domain – ''Lactococcus lactis''
-[[1q3h]] - mCFTR NBD1+AMPPNP<br />
-[[1r0w]] - mCFTR NBD1<br />
+* ABC choline transporters
-[[1r0x]], [[1r0z]], [[1r10]] - mCFTR NBD1+ATP<br />
-[[1r0y]] - mCFTR NBD1+ADP<br />
+**[[3hcq]] - SmABC choline transporter (mutant) – ''Sinorhizobium meliloti''<br />
-[[1ckw]], [[1ckx]], [[1cky]], [[1ckz]] – CFTR F508 region - NMR
+**[[2rin]] - SmABC choline transporter (mutant)+acetylcholine<br />
+**[[2reg]] - SmABC choline transporter (mutant)+choline<br />
+**[[2rej]], [[2rf1]] - SmABC choline transporter (mutant)<br />
+**[[3o66]] – SaABC choline transporter
+* ABC alpha-hemolysin transporters
+**[[2pmk]] - EcABC alpha-hemolysin transporter+TNP-ADP<br />
+**[[2ff7]] - EcABC alpha-hemolysin transporter+ADP<br />
+**[[2ffa]], [[2ffb]] - EcABC alpha-hemolysin transporter (mutant)+ADP<br />
+**[[2fgj]], [[2fgk]], [[2xef]] - EcABC alpha-hemolysin transporter (mutant)+ATP<br />
+**[[3b5j]] - EcABC alpha-hemolysin transporter (mutant)+TNP-ADP<br />
+* ABC various compounds transporters
+**[[2v84]] - ABC spermidine/putrescine transporter – ''Treponema pallidum''<br />
+**[[2qi9]] - EcABC vitamin B12 transporter+BtuD+BtuF<br />
+**[[1l7v]] - EcABC vitamin B12 transporter+BtuD<br />
+**[[3p7i]], [[3qk6]], [[3quj]], [[3s4u]] – EcABC alkylphosphonate transporter PHND + aminoethyl phosphonic acid<br />
+**[[1twy]] - ABC phosphate transporter – ''Vibrio cholerae''<br />
+**[[3l6g]], [[3l6h]] – LlABC OpuAC betaine transporter SBD <br />
+**[[2zzv]] - TtABC solute transporter+lactate+Ca<br />
+**[[2zzw]] - TtABC solute transporter+lactate+Zn<br />
+**[[2zzx]] - TtABC solute transporter+lactate<br />
+**[[3gfv]] - BsABC petrobactin transporter – ''Bacillus subtilis''<br />
+**[[3bk7]] – ABC ATP-binding – ''Pyrococcus abyssi''<br />
+**[[3ppn]] - BsABC multiple solute transporter<br />
+**[[3ppo]], [[3ppp]], [[3ppq]], [[3ppr]] - BsABC multiple solute transporter + solute<br />
+**[[3hn0]] – ABC NO3 transporter – ''Parabacteroides distasonis''<br />
+**[[3rlb]] - LlABC vitamin B1 transporter + thiamin<br />
+**[[4dve]] - LlABC biotin transporter + biotin
+*hABC transporters subfamilies
+**[[3nh6]] – hABCB6 NBD<br />
+**[[3nhb]] – hABCB6 NBD+ADP<br />
+**[[3nh9]] – hABCB6 NBD+ATP<br />
+**[[3nha]] – hABCB6 NBD+ATP+Mg
+* ABC unspecified transporters
+**[[3lvu]] - SpABC transporter SBD <br />
+**[[2ihy]] - SaABC transporter ATPase subunit <br />
+**[[3eaf]] - ABC transporter SBD – ''Aeropyrum pernix''<br />
+**[[3c9h]] - AtABC transporter – ''Agrobacterium tumefaciens''<br />
+**[[1vpl]], [[1ji0]] - TmABC transporter  <br />
+**[[2pcj]], [[2pcl]] - ABC transporter – ''Aquifex aeolicus''<br />
+**[[3rpw]] - ABC transporter – ''Rhodopseudomonas palustris''<br />
+**[[2yl4]] - hABC transporter 10<br />
+**[[4g68]] – ABC transporter - ''Caldanaerobius''
+* Cystic fibrosis transmembrane conductance regulator (CFTR)
+**[[3gd7]] – hCFTR/malK+N6-phenylethyl-ATP<br />
+**[[2pze]], [[2pzf]], [[2pzg]] – hCFTR NBD1<br />
+**[[2bbo]], [[2bbs]], [[2bbt]] - hCFTR NBD1 (mutant)<br />
+**[[1xmi]], [[2xmj]], [[1xmj]] - hCFTR NBD1 (mutant)+ATP<br />
+**[[1xf9]], [[2xfa]], [[1xfa]] - mCFTR NBD1 (mutant) - mouse<br />
+**[[1q3h]] - mCFTR NBD1+AMPPNP<br />
+**[[1r0w]] - mCFTR NBD1<br />
+**[[1r0x]], [[1r0z]], [[1r10]] - mCFTR NBD1+ATP<br />
+**[[1r0y]] - mCFTR NBD1+ADP<br />
+**[[1ckw]], [[1ckx]], [[1cky]], [[1ckz]] – CFTR F508 region - NMR
 }}