Molecular Playground/IntegrinBeta1: Difference between revisions

Integrins binding to the extracellular matrix provide cells with the traction to migrate and regulates their ability to remodel the extracellular matrix. For these reasons, integrins are extremely important in cancer metastasis, and the progression of solid tumors; which often stiffens from ECM remodeling [,]. When cells bind to extracellular matrix proteins with integrins, these proteins can stimulate survival, migration/invasion, and proliferation. Integrins are over expressed in cancer, but targeting integrins to treat cancer has seen limited success. Likely, these failures stem from differential integrin expression between cancer cells, and new technologies to screen cancer cell populations are being developed to screen for affective therapies []. Hopefully these technologies will allow for more selective treatment and better clinical efficacy for integrin inhibitors.