Molecular Playground/IntegrinBeta1: Difference between revisions

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==Integrins and cancer==
==Integrins and cancer==


Integrins binding to the extracellular matrix provide cells the ability to migrate and remodel the surrounding extracellular matrix. For these reasons, integrins are extremely important in cancer metastasis, and the progression of solid tumors; which stiffen over time from ECM remodeling [2,3]. When cells bind to extracellular matrix proteins with integrins, these proteins can stimulate survival, migration/invasion, and proliferation. High expression of integrin beta 1 has been shown to drive primary tumor profession and metastasis, but targeting integrins for cancer treatment has seen limited success [4]. Likely, these failures stem from differential integrin expression between cancer cells, and new technologies to screen cancer cell populations are being developed to screen for affective therapies [5]. Hopefully these technologies will allow for more selective treatment and better clinical efficacy for integrin inhibitors.  
Integrins binding to the extracellular matrix provide cells the ability to migrate and remodel the surrounding microenvironment. For these reasons, integrins are extremely important in cancer metastasis, and the progression of solid tumors. When cells bind to extracellular matrix proteins with integrins, these proteins can stimulate survival, migration/invasion, and proliferation [2]. High expression of integrin beta 1 has been shown to drive primary tumor progression and metastasis, but targeting integrins for cancer treatment has seen limited success [3]. Likely, these failures stem from differential integrin expression between cancer cells, and new technologies to screen cancer cell populations are being developed to screen for affective therapies [4]. These technologies will likely allow for more selective treatment and better clinical efficacy for integrin inhibitors.  


==Studying Integrin Beta-1'' in vitro''==
==Studying Integrin Beta-1'' in vitro''==
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[2] Desgrossellier JS,  and Cheresh DA. Integrins in cancer: biological implications and therapeutic opportunities. Nature Reviews Cancer 10, 9-22 (January 2010) | doi:10.1038/nrc2748
[2] Desgrossellier JS,  and Cheresh DA. Integrins in cancer: biological implications and therapeutic opportunities. Nature Reviews Cancer 10, 9-22 (January 2010) | doi:10.1038/nrc2748


[3] Oranto M, Sarrazy V, Bonte F, Hinz B, Gabbiani G, and Desmouliere A. The role of the myofibroblast in tumor stroma remodeling. Cell Adh Migr 6, 203-219 (2012)
[3]Dos Santos PB, Zanetti JS, Ribeiro-Silva A, Beltrão EIC. Beta 1 integrin predicts survival in breast cancer: a clinicopathological and immunohistochemical study. Diagn Pathol 7:104.(2012)


[4]Dos Santos PB, Zanetti JS, Ribeiro-Silva A, Beltrão EIC. Beta 1 integrin predicts survival in breast cancer: a clinicopathological and immunohistochemical study. Diagn Pathol 7:104.(2012)
[4] Barney LE, Dandley EC, Jansen LE, Reich NG, Mercurio AM, Peyton SR. “A Cell-ECM Screening Method to Predict Breast Cancer Metastasis”. (2014) In Review.
 
[5] Barney LE, Dandley EC, Jansen LE, Reich NG, Mercurio AM, Peyton SR. “A Cell-ECM Screening Method to Predict Breast Cancer Metastasis”. (2014) In Review.
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