Cellobiohydrolase

Cellobiohydrolase (CBH) is a cellulase which degrades cellulose by hydrolysing the 1,4-β-D-glycosidic bonds. CBH is an exocellulase which cleaves two to four units from the ends of cellulose. There are two types of CBH. CBHI cleaves progressively from the reducing end while CBHII cleaves progressively from the nonreducing end of cellulose.

3D structures of cellobiohydrolase

Updated on 15-March-2015

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• Cellobiohydrolase I

• • 1cel – HjCBHI core – Hypocrea jecorina
    
  • 1cbh, 2cbh – HjCBHI C terminal – NMR
    
  • 1azh, 1az6, 1azj, 1azk - HjCBHI cellulose-binding domain (mutant) - NMR
    
  • 2cel, 4cel, 1egn, 1q2b - HjCBHI catalytic domain (mutant)
    
  • 1gpi - PcCBHI catalytic domain – Phanerochaete chrysosporium
    
  • 1q9h, 3pfj - TeCBHI catalytic domain – Talaromyces emersonii
    
  • 2y9l, 2y9n - CBHI catalytic domain – Hypocrea lixii
• Cellobiohydrolase I binary complex
  • 3cel - HjCBHI catalytic domain (mutant) + cellobiose
    
  • 5cel, 1q2e - HjCBHI catalytic domain (mutant) + cellotetraose
    
  • 6cel - HjCBHI catalytic domain (mutant) + cellopentaose
    
  • 7cel - HjCBHI catalytic domain (mutant) + glucose
    
  • 2v3i, 2v3r - HjCBHI catalytic domain + phenanthrenolol
    
  • 1dy4 - TrCBHI catalytic domain + propranolol – Trichoderma reesei
    
  • 1h46 - PcCBHI catalytic domain + propranolol
    
  • 1z3t - PcCBHI catalytic domain + cellobiose
    
  • 1z3v - PcCBHI catalytic domain + lactose
    
  • 1z3w - PcCBHI catalytic domain + cellobioimidazole
    
  • 3pfx - TeCBHI catalytic domain + cellobiose
    
  • 3pfz - TeCBHI catalytic domain + cellotetraose + cellobiose
    
  • 3pl3 - TeCBHI catalytic domain + cellopentaose
    
• Cellobiohydrolase II
  • 3cbh – HjCBHII core
    
  • 1cb2 – HjCBHII catalytic domain (mutant)
    
  • 1hgw, 1hgy, 1oc6 – HjCBHII catalytic domain (mutant)
• Cellobiohydrolase II binary complex
  • 1bvw - HiCBHII catalytic domain + mannose – Humicola insolens
    
  • 2bvw - HiCBHII catalytic domain + glucose + cellotetraose
    
  • 1gz1, 1oc5 - HiCBHII catalytic domain (mutant) + cellotetraose
    
  • 1oc7 - HiCBHII catalytic domain (mutant) + cellopentaose
    
  • 1ocj - HiCBHII catalytic domain + cellopentaose
    
  • 1ocb - HiCBHII catalytic domain + fluorescent substrate
    
  • 1ocn - HiCBHII catalytic domain (mutant) + isofagomine
    
  • 1qjw - TrCBHII catalytic domain (mutant) + cellotetraose
    
  • 1qk0 - TrCBHII catalytic domain + polysaccharide
    
  • 1qk2 - TrCBHII catalytic domain + cellotetraose
    
• Other cellobiohydrolases
  • 1l1y – CtCBH – Clostridium thermocellum
    
  • 1rq5 - CtCBH (mutant)
    
  • 1ut9 - CtCBH catalytic domain
    
  • 1sqj - GeCBH – Geotrichum
    
  • 3a64, 3vog - CcCBH catalytic domain - Coprinopsis cinerea
    
  • 3vof, 3voj - CcCBHI catalytic domain (mutant)
    
  • 4v1z – AfCBH 7A – Aspergillus fumigatus
    
• Other cellobiohydrolases binary complex
  • 1l2a - CtCBH + glucose
    
  • 2ebs – GeCBH (mutant) + heptasaccharide
    
  • 3a9b, 3voh - CcCBHI catalytic domain + cellobiose
    
  • 3abx, 3voi - CcCBHI catalytic domain + cellotriose
    
  • 4v20 - AfCBH 7A + disaccharide
    

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