Granzyme: Difference between revisions
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<StructureSection load='1fq3' size='400' side='right' caption='Structure of glycosylated human granzyme B dimer complex with sulfate (PDB entry [[1fq3]])' scene=''> | <StructureSection load='1fq3' size='400' side='right' caption='Structure of glycosylated human granzyme B dimer complex with sulfate (PDB entry [[1fq3]])' scene=''> | ||
'''Granzymes''' (GZM) are serine proteases which induce apoptosis in virus-infected cells. | '''Granzymes''' (GZM) are serine proteases which induce apoptosis in virus-infected cells<ref>PMID:17158907</ref>.<br /> | ||
*'''Granzyme A and K''' is the most abundant serine protease in killer cells cytotoxic granules <ref>PMID:20536557</ref>.<br /> | |||
*'''Granzyme B and C''' induces cytotoxic T lymphocyte-mediated target cell apoptosis <ref>PMID:12752668</ref>.<br /> | |||
*'''Granzyme H''' helps granzyme B kill adenovirus-infected cells <ref>PMID:17766182</ref>.<br /> | |||
*'''Granzyme M''' induces target cell death, inhibits viral replication and regulates inflammation <ref>PMID:24413154</ref>.<br /> | |||
</StructureSection> | </StructureSection> | ||
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**[[2zgj]] – hGZM (mutant) + polypeptide<br /> | **[[2zgj]] – hGZM (mutant) + polypeptide<br /> | ||
}} | }} | ||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:35, 16 March 2016
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3D structures of granzyme
Updated on 16-March-2016
