Major histocompatibility complex

spinqualitylabelsall models Human MHC class I complex (grey) withβ 2-microglobulin (green), 2hla Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Major Histocompatibility Complex (MHC) are part of the cell immune system. MHC molecules display antigens on the host cell’s surface. T cell or natural killer receptors recognize the MHC:peptide and activate the immune response. MHC class I (Major Histocompatibility Complex Class I) are found in all nucleated cells. For more details see Effect of HCMV on Major Histocompatibility Complex Class I MR1 Binds Vitamin Metabolites. MHC class II are found in professional antigen-presenting cells like macrophages. 3D structures of MHC Updated on 01-December-2014 {"openlevels":0} MHC I MHC I binary complex 1zs8 - mMHC I + β-2-microglobulin – mouse 2hla, 3hla, 1hla - hMHC I + β-2-microglobulin – human 3p73, 3p77 - cMHC I + β-2-microglobulin – chicken MHC I ternary complex 2yf6, 3bew, 2yez, 2yf1, 2yf5, 3bev – cMHC I α + β-2-microglobulin + peptide 3kpn, 3kpo – hMHC I B + β-2-microglobulin + peptide 3bev, 1kpr, 1k5n, 3nfn, 3mr9, 3mrb, 3mrc, 3mrd, 3mre, 3mrf, 3mrg, 3mrh, 3mri, 3mrj, 3mrk, 3mrl, 3mrm, 3mrn, 3mro, 3mrp, 3mrq, 3mrr, 3ox8, 3oxr, 3oxs, 2xpg, 3pwj, 3pwl, 3pwn, 3pwp, 2x70, 3o3a, 3o3b, 3o3d, 3o3e, 3lv3, 3ln4, 3ln5, 3myj, 3i6l, 3lkn, 3lko, 3lkp, 3lkq, 3lkr, 3lks, 3hpj, 3i6g, 3i6k, 3mgo, 3mgt, 3l3d, 3l3g, 3l3i, 3l3j, 3l3k, 2x4n, 2x4o, 2x4p, 2x4q, 2x4r, 2x4s, 2x4t, 2x4u, 3lka, 3h7b, 3kpl, 3kpm, 3kpn, 3kpo, 3kpp, 3kpq, 3kpr, 3kps, 3giv, 3hcv, 3d18, 3dtx, 3czf, 3fqn, 3fqr, 3fqt, 3fqu, 3fqw, 3fqx, 3d25, 3bvn, 3dx6, 3dx7, 3dx8, 3dxa, 3bo8, 3bp4, 3bp7, 3bgm, 3bh8, 3bh9, 3bhb, 3b3i, 3b6s, 2rfx, 3bze, 3bzf, 3bw9, 3bwa, 3c9n, 2v2w, 2v2x, 2gt9, 2gtw, 2gtz, 2guo, 2nw3, 2fyy, 2fz3, 2hn7, 2cik, 2git, 2hjk, 2hjl, 2h6p, 2d31, 2c7u, 2bck, 2a83, 2axf, 2axg, 2bvo, 2bvp, 2bvq, 1s8d, 1t1w, 1t1x, 1t1y, 1t1z, 1t20, 1t21, 1t22, 1s7q, 1zsd, 2bsr, 2bss, 2bst, 1zhk, 1zhl, 1tvb, 1tvh, 1xr8, 1xr9, 1w0v, 1w0w, 1xh3, 1uxs, 1uxw, 1s9w, 1s9x, 1s9y, 1q94, 1qvo, 1n2r, 1ogt, 1qew, 1jge, 1k5n, 1i7r, 1i7t, 1i7u, 1jf1, 1jht, 1i4f, 1e27, 1e28, 1i1y, 1i1f, 1qqd, 1mhe, 1b0g, 1a9b, 1a9e, 1a1m, 1a1n, 1a1o, 1tmc, 2clr, 1hhg, 1hhh, 1hhi, 1hhj, 1hhk, 1hsb, 1hsa, 3to2, 2vab - hMHC I α + β-2-microglobulin + peptide 1ktl, 3kww, 3h9h, 3ixa, 3gso, 3gsq, 3gsr, 3gsu, 3gsv, 3gsw, 3gsx, 3ft2, 3ft3, 3ft4, 2av1, 2av7, 1cg9, 1m05, 1m6o, 1kpr, 1ktl - hMHC I α (mutant) + β-2-microglobulin + peptide 1syv, 1n2r, 1syv - hMHC I + β-2-microglobulin + hMHC II peptide 1kjv, 1kjm, 1ed3 – MHC I α + β-2-microglobulin + peptide - rat 2oi9 - mMHC I α + T cell receptor + peptide 1kbg, 3l3h, 3ftg, 3e6f, 3ecb, 3ch1, 3cch, 3cc5, 3cpl, 2zsv, 2zsw, 2zok, 2zol, 3buy, 2ve6, 2e7l, 2fo4, 2cii, 2fwo, 2f74, 1zt1, 1zt7, 1vgk, 1yn6, 1yn7, 1zhb, 1wbx, 1wby, 1wbz, 1rjy, 1rjz, 1rk0, 1rk1, 1t0m, 1t0n, 1s7q, 1s7r, 1s7s, 1s7t, 1s7u, 1s7v, 1s7w, 1s7x, 1lk2, 1kpu, 1kpv, 1n3n, 1nan, 1n59, 1n5a, 1ffn, 1ffo, 1ffp, 1g7p, 1g7q, 1lek, 1leg, 1inq, 1juf, 1k8d, 1jpf, 1jpg, 1fg2, 1qlf, 1bz9, 1kbg, 1hoc, 2mha, 1vad, 1vac, 3roo, 3quk, 3qul, 3rol, 3tbs, 3tbt, 3tbv, 3tbw, 3tbx, 3tby - mMHC I + β-2-microglobulin + peptide 2qri - mMHC I/β-2-microglobulin/peptide 2qrs, 2qrt - mMHC I (mutant)/β-2-microglobulin/peptide 1mhc, 2clv, 2clz, 1fzj, 1fzk, 1fzm, 1fzo, 1ddh - mMHC I (mutant) + β-2-microglobulin + peptide 3e2h, 3e3q, 2e7l - mMHC I α (mutant) + T cell receptor + peptide 1nez - mMHC I + β-2-microglobulin + CD8 α chain 3rwc, 3rwd, 3rwe, 3rwf, 3rwg, 3rwh, 3rwi, 3rwj - MHC I + β-2-microglobulin + peptide – Rhesus macaque 3qq3, 3qq4 - MHC I + β-2-microglobulin + peptide - pig MHC I quaternary complex 3qdg, 3qdj, 3qdm, 3qeq, 3mv7, 3mv9, 3h9s, 3gsn, 3d39, 3d3v, 3ffc, 2vlj, 2vlk, 2vll, 2vlr, 2j8u, 2p5e, 2p5w, 2pye, 2gj6, 2f54, 2esv, 2bnq, 2bnr, 1lp9, 1oga, 1mi5, 1qrn - hMHC I α + T cell receptor + β-2-microglobulin + peptide 3kxf, 3mv8, 2jcc, 2uwe - hMHC I α (mutant) + T cell receptor + β-2-microglobulin + peptide 2f53 - hMHC I α + T cell receptor + β-2-microglobulin (mutant) + peptide 1p7q, 1im9 - hMHC I α + leukocyte immunoglobulin-like receptor + β-2-microglobulin + peptide 2dyp - hMHC I α (mutant) + leukocyte immunoglobulin-like receptor + β-2-microglobulin + peptide 3qzw, 3dmm, 1bqh, 1akj - hMHC I α + β-2-microglobulin + CD8 α + peptide 1im3 - hMHC I α + β-2-microglobulin + cytomegalovirus protein US2 + peptide 3cii, 3cdg - hMHC I α + β-2-microglobulin + CD94 ectodomain + NKG2A/NKG2B integral membrane protein + peptide 3hae, 3gjf, 3cvh, 1w72 - hMHC I α + β-2-microglobulin + antibody + peptide 1g6r, 2ckb, 3pqy, 2z31, 1nam, 1mwa, 1g6r, 2ckb - mMHC I + T cell receptor + β-2-microglobulin + peptide 2oi9 - mMHC I (mutant) + T cell receptor + β-2-microglobulin + peptide 1p1z, 1p4l, 1qo3 - mMHC I + β-2-microglobulin + natural killer cell receptor LY49C + peptide 3c8k - mMHC I (mutant) + β-2-microglobulin + natural killer cell receptor LY49C + peptide MHC II 3lqz, 2bc4, 1hdm - hMHC II α+β 3pdo, 3pgc, 3pgd, 1a6a - hMHC II α+β+γ 3cup, 2p24, 1lnu, 1fng - mMHC II α+β 1fne - mMHC II α+β (mutant) 3lqz - hMHC II α+β DP2 MHC II binary complex 1h15 - hMHC II α+β + DNA polymerase peptide 1fv1 - hMHC II α+β + myelin basic protein 3o6f, 2wbj - hMHC II α+β + T cell receptor 3l6f, 3c5j, 2q6w, 2fse, 1t5w, 1s9v, 1uvq, 1h15, 1fv1 – hMHC II α+β + peptide 1dlh - hMHC II α+β + enterotoxin 3c5z, 3c60, 3c6l - mMHC II α+β + T cell receptor 1r5v, 1k2d, 1muj, 1kt2, 1ktd, 1f3j, 1es0, 1iak, 1iea, 1ieb, 1f3j - mMHC II α+β + peptide 1aqd - mMHC II α+β + MHC I peptide 1r5w, 1i3r - mMHC II α+β (mutant) + peptide MHC II ternary complex 1zgl, 1j8h, 1fyt - hMHC II α+β + T cell receptor + peptide 2iam, 2ian, 1ymm – hMHC II α+β + T cell receptor (mutant) + peptide 2ipk, 2g9h, 1pyw, 1jwm, 1jws, 1jwu, 1klg, 1klu, 1hxy, 1d5m, 1d5x, 1d5z, 1d6e, 2seb, 1seb - hMHC II α+β + enterotoxin + peptide 1sje, 1sjh, 1t5x, 1lo5 - hMHC II α+β + enterotoxin (mutant) + peptide 1r5i - hMHC II α+β + mycoplasma arthritidis mitogen+ peptide 2oje - mMHC II α+β + mycoplasma arthritidis mitogen+ peptide 2xn9, 3qib, 1zgl, 3qiu, 3qiw, 3mbe - mMHC I + T cell receptor + peptide 2pxy, 1u3h - mMHC II α+β + T cell receptor (mutant) + peptide 1jl4 - mMHC II α+β + CD4 + peptide MHC II quaternary complex 2icw - mMHC II α+β + T cell receptor + mycoplasma arthritidis mitogen+ peptide

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Tihitina Y Aytenfisu, Michal Harel, Eric Martz, Alexander Berchansky, Sandra B. Gabelli, Joel L. Sussman