NF-kB: Difference between revisions

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== Function ==

'''NF-kB''' or '''Nuclear Factor NF-kappa''' is a DNA transcription factor. It is involved in cellular response to stimuli. NF-kB contains a Rel homology domain (RHR) which contains 2 immunoglobulin-like subdomains which interact with the major groove of DNA. There are 5 proteins in the NF-kB family: '''NF-kB1''' (synthesized as '''p105''' and processed to '''p50'''), '''NF-kB2''' (synthesized as '''p100''' and processed to '''p52'''), '''RelA''' (or '''p65'''), '''RelB''' ~~and~~ '''cRel'''. I-~~κ-B-α is an inhibitor of~~ NF-kB.

'''NF-kB''' or '''Nuclear Factor NF-kappa''' is a DNA transcription factor. It is involved in cellular response to stimuli. NF-kB contains a Rel homology domain (RHR) which contains 2 immunoglobulin-like subdomains which interact with the major groove of DNA<ref>PMID:15371334</ref>. I-κ-B-α is an inhibitor of NF-kB.

There are 5 proteins in the NF-kB family:

*'''NF-kB1''' (synthesized as '''p105''' and processed to '''p50''')

*'''NF-kB2''' (synthesized as '''p100''' and processed to '''p52''')

*'''RelA''' (or '''p65''')

*'''RelB'''

*'''cRel'''.

== Relevance ==

NF-kB plays a critical role in cancer development and progression and may determine its response to therapy. NF-kB is a target for chemotherapeutic agents<ref>PMID:16673382</ref>.

</StructureSection>

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**[[3jv4]] – hp105 dimerization domain + RelB dimerization domain

}}

== References ==

[[Category:Topic Page]]

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 <StructureSection load='1nfk' size='350' side='right' caption='Structure of mouse NF-kB1 p50 complex with DNA (PDB entry [[1nfk]])' scene=''>
+== Function ==
-'''NF-kB''' or '''Nuclear Factor NF-kappa''' is a DNA transcription factor.  It is involved in cellular response to stimuli.  NF-kB contains a Rel homology domain (RHR) which contains 2 immunoglobulin-like subdomains which interact with the major groove of DNA.  There are 5 proteins in the NF-kB family: '''NF-kB1''' (synthesized as '''p105''' and processed to '''p50'''), '''NF-kB2''' (synthesized as '''p100''' and processed to '''p52'''), '''RelA''' (or '''p65'''), '''RelB''' and '''cRel'''.  I-κ-B-α is an inhibitor of NF-kB.
+'''NF-kB''' or '''Nuclear Factor NF-kappa''' is a DNA transcription factor.  It is involved in cellular response to stimuli.  NF-kB contains a Rel homology domain (RHR) which contains 2 immunoglobulin-like subdomains which interact with the major groove of DNA<ref>PMID:15371334</ref>.  I-κ-B-α is an inhibitor of NF-kB.<br />
+There are 5 proteins in the NF-kB family:<br />
+*'''NF-kB1''' (synthesized as '''p105''' and processed to '''p50''')<br />
+*'''NF-kB2''' (synthesized as '''p100''' and processed to '''p52''')<br />
+*'''RelA''' (or '''p65''')<br />
+*'''RelB'''<br />
+*'''cRel'''.
+== Relevance ==
+NF-kB plays a critical role in cancer development and progression and may determine its response to therapy.  NF-kB is a target for chemotherapeutic agents<ref>PMID:16673382</ref>.
 </StructureSection>
@@ Line 39: / Line 48: @@
 **[[3jv4]] – hp105 dimerization domain + RelB dimerization domain<br />
 }}
+== References ==
+<references/>
 [[Category:Topic Page]]