Molecular Playground/IntegrinBeta1: Difference between revisions
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'''Banner:''' Studying integrin-mediated metastasis ''in vitro'' | '''Banner:''' Studying integrin-mediated metastasis ''in vitro'' | ||
<Structure load='3VI4' size='350' frame='true' align='right' caption='Integrin Beta 1 Alpha 5' scene='60/609772/Integrinb1alpha5/1' /> | <Structure load='3VI4' size='350' frame='true' align='right' caption='Integrin Beta 1 Alpha 5 (PDB code [[3vi4]]).' scene='60/609772/Integrinb1alpha5/1' /> | ||
==Structure== | ==Structure== | ||
Integrins are surface proteins that are comprised of an alpha subunit and a beta subunit to form a functional transmembrane structure. The subunits of the heterodimer each have small cytoplasmic domains for signal transduction within the cell. There are 18 alpha and eight beta subunits in mammals. Different pairs of these alpha and beta subunits uniquely bind to extracellular proteins. Integrins connect the extracellular environment to the inside of a cell by inducing signals that affect cell functions. | '''Integrins''' are surface proteins that are comprised of an alpha subunit and a beta subunit to form a functional transmembrane structure. The subunits of the heterodimer each have small cytoplasmic domains for signal transduction within the cell. There are 18 alpha and eight beta subunits in mammals. Different pairs of these alpha and beta subunits uniquely bind to extracellular proteins. Integrins connect the extracellular environment to the inside of a cell by inducing signals that affect cell functions. | ||
The protein structure on the right has the following color coding: Blue-Alpha 5 chain, Red-Beta 1 chain, Grey-SG/19 Fab fragment light chain, Green-SG/19 Fab fragment heavy chain. | The protein structure on the right has the following color coding: Blue-Alpha 5 chain, Red-Beta 1 chain, Grey-SG/19 Fab fragment light chain, Green-SG/19 Fab fragment heavy chain. | ||
