Plasminogen: Difference between revisions
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{{STRUCTURE_1qrz| PDB=1qrz | SIZE=400| SCENE= |right|CAPTION=Human plasmin catalytic domain tetramer, [[1qrz]] }} | {{STRUCTURE_1qrz| PDB=1qrz | SIZE=400| SCENE= |right|CAPTION=Human plasmin catalytic domain tetramer, [[1qrz]] }} | ||
'''Plasmin''' (PLN) is a serine protease which is involved in degradation of fibrin clots. PLN is released as the zymogen '''plasminogen''' (PLG) which is converted to the active PLN by a variety of enzymes. PLN cleavage produces angiostatin. PLN domains are: N-terminal, C-terminal serine protease catalytic domain and 5 kringle domains of ca. 80 residues. | '''Plasmin''' (PLN) is a serine protease which is involved in degradation of fibrin clots. PLN is released as the zymogen '''plasminogen''' (PLG) which is converted to the active PLN by a variety of enzymes. PLN cleavage produces angiostatin. PLN domains are: N-terminal, C-terminal serine protease catalytic domain and 5 kringle domains of ca. 80 residues. The kringle domain folds into a large loop containing 3 disulfide bonds. The kringle domain is important in protein-protein interaction with blood coagulation factors. | ||
== 3D Structures of plasminogen == | == 3D Structures of plasminogen == | ||
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**[[1cea]] - hPLG kringle 1 + e-aminocaprioic acid<BR /> | **[[1cea]] - hPLG kringle 1 + e-aminocaprioic acid<BR /> | ||
**[[1hpj]], [[1hpk]] - hPLG kringle 1 + 6-aminohexanoic acid - NMR<BR /> | **[[1hpj]], [[1hpk]] - hPLG kringle 1 + 6-aminohexanoic acid - NMR<BR /> | ||
**[[1ceb]] - hPLG kringle 1 + AMCHA | **[[1ceb]] - hPLG kringle 1 + AMCHA<br /> | ||
**[[4cik]] - hPLG kringle 1 + inhibitor<br /> | |||
*Plasminogen kringle 2 | *Plasminogen kringle 2 | ||
