Emily Ellis/Sandbox

Two 3D printed objects and a box

<qt>file=Image:salbutamol.mp4|autoplay=false|width=600|height=460|controller=true|loop=false</qt>

A drug and its mirror image

Are the molecules shown on the left below and on the right identical, or are they different from each other? You can rotate the molecule on the right with your mouse to match the molecule on the left.

spinqualitylabelsall models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D It turns out that some molecules, such as the drug salbutamol we are using as an example here, are different from their mirror image. The left image shows the actual drug, while the browser on the right shows its mirror image. If you click on the green link, we'll show the actual drug in the browser as well, and you can rotate it with the mouse to show how they match. So far we focused on the shape of the molecule. To fully understand how salbutamol binds, we should show you what atoms it is made of. If you click on the "Show the atoms" link below, carbon atoms will appear in gray, oxygen atoms in red, and nitrogen atoms in blue. The molecule also contains hydrogen atoms, but these are much smaller and are not shown. What about the box? When salbutamol acts in the body, it does so by binding to a receptor in the cell membrane. Receptors help to communicate between the outside of the cell and the inside of the cell, much like a window or a door bell helps people in a house learn about what is going on outside. The receptor salbutamol binds to is a protein called the adrenergic receptor. It's a big molecule, and salbutamol is difficult to see because it is surrounded by the receptor, especially if we show name='61/611451/Adrenergic_receptor/7'>all the atoms</scene>. Use the links below to "shave away" parts of the molecule for a better look inside The next scene shows salbutamol in red, and those parts of the receptor that surround it, called its binding site, in blue. Compare the blue parts to the box in the movie. It helps to use the "shave away" buttons above, and to rotate the view so it matches the view of the molecule in the movie. Binding Site

Leftovers

adrenergic receptor.

Proteopedia Page Contributors and Editors (what is this?)

Emily Ellis, Karsten Theis, Marius Mihasan