3gg6: Difference between revisions
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gg6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gg6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gg6 RCSB], [http://www.ebi.ac.uk/pdbsum/3gg6 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gg6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gg6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gg6 RCSB], [http://www.ebi.ac.uk/pdbsum/3gg6 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/NUD18_HUMAN NUD18_HUMAN]] Mediates the hydrolyzis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8-oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Hydrolyzes also 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolyzis activity against 8-oxo-dGTP, 8-oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools. | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 21:59, 25 December 2014
Crystal structure of the NUDIX domain of human NUDT18
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Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Homo sapiens
- Arrowsmith, C H
- Berg, S Van Den
- Berglund, H
- Bountra, C
- Collins, R
- Dahlgren, L G
- Edwards, A M
- Flodin, S
- Flores, A
- Graslund, S
- Hammarstrom, M
- Johansson, A
- Johansson, I
- Karlberg, T
- Kotenyova, T
- Lehtio, L
- Moche, M
- Nilsson, M E
- Nordlund, P
- Nyman, T
- Persson, C
- Structural genomic
- Sagemark, J
- Schueler, H
- Siponen, M I
- Thorsell, A G
- Tresaugues, L
- Weigelt, J
- Welin, M
- Wisniewska, M
- Hydrolase
- Magnesium
- Manganese
- Metal-binding
- Nucleotide hydrolase
- Nudix
- Nudt18
- Nxr1
- Sgc
- Sgc stockholm
