3h78: Difference between revisions

Line 9:

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3h78 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h78 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3h78 RCSB], [http://www.ebi.ac.uk/pdbsum/3h78 PDBsum]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/PQSD_PSEAE PQSD_PSEAE]] Required for the biosynthesis of a number of signaling molecules, such as the quinolone signal 2-heptyl-3-hydroxy-4(1H)-quinolone (PQS), 2-heptyl-4-hydroxyquinoline (HHQ) and 2,4-dihydroxyquinoline (DHQ). These molecules are required for normal biofilm formation. The exact reaction mechanism is still under debate. According to PubMed:18728009, a covalent anthraniloyl-PqsD intermediate is formed, which then condenses with malonyl-CoA or malonyl-acyl carrier protein (malonyl-ACP) to form the short-lived intermediate 3-(2-aminophenyl)-3-oxopropanoyl-CoA. An intramolecular rearrangement of this intermediate can give rise to 2,4-dihydroxyquinoline (DHQ) (in vitro). Alternatively (PubMed:21425231), DHQ and HHQ biosynthesis could proceed via a decarboxylative Claisen condensation of a beta-ketoacid and anthraniloyl-CoA.<ref>PMID:18728009</ref> <ref>PMID:19694421</ref> <ref>PMID:21425231</ref> <ref>PMID:22992202</ref>

== Evolutionary Conservation ==

[[Image:Consurf_key_small.gif|200px|right]]

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@@ Line 9: / Line 9: @@
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3h78 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h78 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3h78 RCSB], [http://www.ebi.ac.uk/pdbsum/3h78 PDBsum]</span></td></tr>
 </table>
+== Function ==
+[[http://www.uniprot.org/uniprot/PQSD_PSEAE PQSD_PSEAE]] Required for the biosynthesis of a number of signaling molecules, such as the quinolone signal 2-heptyl-3-hydroxy-4(1H)-quinolone (PQS), 2-heptyl-4-hydroxyquinoline (HHQ) and 2,4-dihydroxyquinoline (DHQ). These molecules are required for normal biofilm formation. The exact reaction mechanism is still under debate. According to PubMed:18728009, a covalent anthraniloyl-PqsD intermediate is formed, which then condenses with malonyl-CoA or malonyl-acyl carrier protein (malonyl-ACP) to form the short-lived intermediate 3-(2-aminophenyl)-3-oxopropanoyl-CoA. An intramolecular rearrangement of this intermediate can give rise to 2,4-dihydroxyquinoline (DHQ) (in vitro). Alternatively (PubMed:21425231), DHQ and HHQ biosynthesis could proceed via a decarboxylative Claisen condensation of a beta-ketoacid and anthraniloyl-CoA.<ref>PMID:18728009</ref> <ref>PMID:19694421</ref> <ref>PMID:21425231</ref> <ref>PMID:22992202</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]