3raw: Difference between revisions
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3raw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3raw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3raw RCSB], [http://www.ebi.ac.uk/pdbsum/3raw PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3raw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3raw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3raw RCSB], [http://www.ebi.ac.uk/pdbsum/3raw PDBsum]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/CLK3_HUMAN CLK3_HUMAN]] Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.<ref>PMID:9637771</ref> <ref>PMID:19168442</ref> | |||
==See Also== | ==See Also== | ||
*[[Dual specificity protein kinase|Dual specificity protein kinase]] | *[[Dual specificity protein kinase|Dual specificity protein kinase]] | ||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 18:54, 25 December 2014
Crystal Structure of human CDC-like kinase 3 isoform in complex with leucettine L41
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Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Dual-specificity kinase
- Homo sapiens
- Arrowsmith, C H
- Bazureau, J P
- Bountra, C
- Bullock, A
- Carreaux, F
- Debdab, M
- Delft, F von
- Edwards, A M
- Fedorov, O
- Filippakopoulos, P
- King, O
- Knapp, S
- Meijer, L
- Muniz, J R.C
- Renault, S
- Structural genomic
- Weigelt, J
- Kinase
- Nucleotide-binding
- Serine/threonine-protein kinase
- Sgc
- Transferase
- Tyrosine-protein kinase
