3p3k

The crystal structure of translationally controlled tumor protein (TCTP) of Plasmodium falciparum

spinqualitylabelsall models 3p3k, resolution 2.55Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3p3k is a 1 chain structure with sequence from Plasmodium falciparum 3d7. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Related: 1txj Gene: TCTP, PFE0545c (Plasmodium falciparum 3D7) Resources: FirstGlance, OCA, RCSB, PDBsum Function [TCTP_PLAF7] Involved in calcium binding and microtubule stabilization. Publication Abstract from PubMed Malaria causes millions of death cases per year. Since Plasmodium falciparum rapidly develops drug resistance, it is of high importance to investigate potential drug targets which may lead to novel rational therapy approaches. Here we report on the interaction of translationally controlled tumor protein of Plasmodium falciparum (PfTCTP) with the anti-malarial drug artemisinin. Furthermore, we investigated the crystal structure of PfTCTP. Using mass spectrometry, bioinformatic approaches and surface plasmon resonance spectroscopy, we identified novel binding sites of artemisinin which are in direct neighborhood to amino acids 19-46, 108-134 and 140-163. The regions covered by these residues are known to be functionally important for TCTP function. We conclude that interaction of artemisinin with TCTP may be at least in part explain the antimalarial activity of artemisinin. Molecular interaction of artemisinin with translationally controlled tumor protein (TCTP) of Plasmodium falciparum.,Eichhorn T, Winter D, Buchele B, Dirdjaja N, Frank M, Lehmann WD, Mertens R, Krauth-Siegel RL, Simmet T, Granzin J, Efferth T Biochem Pharmacol. 2012 Oct 17. pii: S0006-2952(12)00678-8. doi:, 10.1016/j.bcp.2012.10.006. PMID:23085438 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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