3nr9: Difference between revisions
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nr9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nr9 RCSB], [http://www.ebi.ac.uk/pdbsum/3nr9 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nr9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nr9 RCSB], [http://www.ebi.ac.uk/pdbsum/3nr9 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/CLK2_HUMAN CLK2_HUMAN]] Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.<ref>PMID:10480872</ref> <ref>PMID:19168442</ref> <ref>PMID:8910305</ref> <ref>PMID:9637771</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
*[[Dual specificity protein kinase|Dual specificity protein kinase]] | *[[Dual specificity protein kinase|Dual specificity protein kinase]] | ||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 01:35, 25 December 2014
Structure of human CDC2-like kinase 2 (CLK2)
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Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Dual-specificity kinase
- Homo sapiens
- Arrowsmith, C H
- Berridge, G
- Bountra, C
- Chaikuad, A
- Delft, F von
- Edwards, A M
- Eswaran, J
- Fedorov, O
- Filippakopoulos, P
- Keates, T
- Knapp, S
- Krojer, T
- Muniz, J R.C
- Phillips, C
- Pike, A C.W
- Rellos, P
- Structural genomic
- Savitsky, P
- Weigelt, J
- Zhang, Y
- Dual specificity protein kinase
- Protein kinase
- Sgc
- Transferase
